ALKALOIDS FROM CATECHOLAMINES IN ADRENAL TISSUE - POSSIBLE ROLE IN ALCOHOLISM
ALKALOIDS FROM CATECHOLAMINES IN ADRENAL TISSUE - POSSIBLE ROLE IN ALCOHOLISM
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DOI：
10.1126/science.167.3926.1749
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发表时间：
1970-01-01
期刊：
影响因子：
56.9
通讯作者：
COLLINS, M
中科院分区：
文献类型：
--
作者：
COHEN, G;COLLINS, M
肾上腺素和去甲肾上腺素与乙醛或甲醛在稀水溶液中于中性pH和室温下缩合生成1，2，3，4-四氢异喹啉生物碱。在37°C下用稀醛溶液灌注的牛肾上腺中也发生了类似的缩合反应。这些生物碱在体内的生物合成可能在改变个体摄入酒精期间和之后的行为方面发挥作用。
Epinephrine and norepinephrine condensed with acetaldehyde or with formaldehyde in dilute aqueous solution at neutralpH and room temperature to form 1,2,3,4-tetrahydroisoquinoline alkaloids. Similar condensation reactions occurred in cow adrenal glands perfused with dilute aldehyde solutions at 37°C. Biosynthesis of these alkaloids in vivo could play a role in altering an individual's behavior during and after the ingestion of alcohol.