Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy
Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy
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DOI：
10.1016/s0968-0896(02)00039-1
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发表时间：
2002-07-01
影响因子：
3.5
通讯作者：
Brahmachary, E
中科院分区：
文献类型：
--
作者：
Kotha, S;Brahmachary, E
描述了一种含有氨基酸部分的二烷基构筑块(6，7，8和9)的简单合成方法。在Wilkinson催化剂存在下，二酮6参与了与各种单炔的[2+2+2]环加成反应，得到了5-和5，6-二取代吲哚基α-氨基酸衍生物。钴催化剂[例如，CPCO(CO)(2)]也被用于通过二炔构筑块6和7与几个单炔的共聚反应合成各种2-吲哚甘氨酸衍生物。(C)2002爱思唯尔科学有限公司。保留所有权利。
A simple synthesis of dialkyne building blocks (6,7,8 and 9) embodying amino acid moiety is described. The dialkyne 6 participated in a [2 + 2+ 2] cycloaddition reaction with various monoalkynes in presence of Wilkinson's catalyst to give 5- and 5,6-disubstitued indan-based alpha-amino acid derivates. Cobalt catalyst [e.g., CpCo(CO)(2)] has also been employed in the synthesis of various 2-indanyl glycine derivatives via co-trimerization reaction of the diyne building blocks 6 and 7 with several monoalkynes. (C) 2002 Elsevier Science Ltd. All rights reserved.