Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine
Polyvinylpyrrolidone-Poly(ethylene glycol) Modified Silver Nanorods Can Be a Safe, Noncarrier Adjuvant for HIV Vaccine
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聚乙烯吡咯烷酮-聚乙二醇修饰的银纳米棒可以成为 HIV 疫苗的安全非载体佐剂
DOI：
10.1021/acsnano.5b08025
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发表时间：
2016-03-01
期刊：
影响因子：
17.1
通讯作者：
Jiang, Xingyu
中科院分区：
文献类型：
--
作者：
Liu, Ye;Balachandran, Yekkuni L.;Jiang, Xingyu
HIV疫苗开发的最大障碍之一是如何通过安全的方式充分激发关键的抗HIV免疫。本文综合了表面修饰依赖的免疫刺激和形状依赖的生物安全性，设计了一种安全的非载体佐剂，该佐剂基于聚乙烯吡咯烷酮（PVP）和聚乙二醇（PEG）包覆的银纳米棒。这种银纳米棒可以显著提高HIV疫苗的关键免疫力，并克服毒性，这是其他现有佐剂的一个大问题。本研究为设计安全高效的佐剂材料提供了原则，使研究人员能够真正安全有效地预防HIV。我们希望这种材料方法适用于其他类型的疫苗，无论是预防性的还是治疗性的。
One of the biggest obstacles for the development of HIV vaccines is how to sufficiently trigger crucial anti-HIV immunities via a safe manner. We herein integrated surface modification-dependent immunostimulation against HIV vaccine and shape-dependent biosafety and designed a safe noncarrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). Such silver nanorods can significantly elevate crucial immunities of HIV vaccine and overcome the toxicity, which is a big problem for other existing adjuvants. This study thus provided a principle for designing a safe and high-efficacy material for an adjuvant and allow researchers to really have a safe and effective prophylaxis against HIV. We expect this material approach to be applicable to other types of vaccines, whether they are preventative or therapeutic.