Quantitative studies on fabrics as disseminators of viruses. 3. Persistence of vaccinia virus on fabrics impregnated with a virucidal agent.
Quantitative studies on fabrics as disseminators of viruses. 3. Persistence of vaccinia virus on fabrics impregnated with a virucidal agent.
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对织物作为病毒传播者的定量研究。
DOI：
10.1128/aem.21.2.227-234.1971
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发表时间：
1967
期刊：
影响因子：
--
通讯作者：
E. McNeil
中科院分区：
文献类型：
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作者：
R. Sidwell;G. J. Dixon;E. McNeil
在体外测试了八种化合物对脊髓灰质炎病毒和牛痘病毒的杀病毒和抗病毒活性。这些化合物包括五种季铵盐、两种溴水杨酰苯胺和一种抗生素硫酸新霉素。没有一种化合物具有抗脊髓灰质炎病毒的活性，但证明了三种季铵化合物具有抗牛痘病毒的杀病毒活性：正烷基（C14，C12，C16）二甲基苄基氯化铵，二异丁基甲苯氧基乙氧基乙基二甲基苄基氯化铵一水合物，和正烷基（60%C14、30%C16、5%C12、5%C18）二甲基苄基氯化铵加正烷基（50%C12、30%C14、17%C16、3%C18）二甲基乙基苄基氯化铵。用上述第一种杀病毒化合物浸渍羊毛毛毯、羊毛华达呢和棉床单材料，并将这些织物上的牛痘病毒的持久性与在25 ℃、35%和78%相对湿度下保持的相同类型的未浸渍织物上的该试剂的持久性进行比较。在病毒暴露后的任何时间，没有病毒可以从化学处理的织物中恢复，而病毒在未浸渍的材料上持续长达4周。还发现活牛痘病毒在用免烫改性三嗪酮树脂整理的棉织物上持续少于1天。脊髓灰质炎病毒在这种免烫织物上的持续时间少于5天。
Eight compounds were tested in vitro for virucidal and antiviral activity against poliovirus and vaccinia virus. These compounds included five quaternary ammonium salts, two bromosalicylanilides, and neomycin sulfate, an antibiotic. None of the compounds was active against poliovirus, but virucidal activity was demonstrated against vaccinia virus with three of the quarternary ammonium compounds: n-alkyl (C14, C12, C16) dimethyl benzyl ammonium chloride, di-isobutyl cresoxy ethoxy ethyl dimethyl benzyl ammonium chloride monohydrate, and n-alkyl (60% C14, 30% C16, 5% C12, 5% C18) dimethyl benzyl ammonium chlorides plus n-alkyl (50% C12, 30% C14, 17% C16, 3% C18) dimethyl ethylbenzyl ammonium chlorides. Wool blanketing, wool gabardine, and cotton sheeting materials were impregnated with the first of the above virucidal compounds, and the persistence of vaccinia virus on these fabrics was compared with the persistence of the agent on nonimpregnated fabrics of the same type held at 25 C in 35 and 78% relative humidity. No virus could be recovered from the chemically treated fabrics at any time after virus exposure, whereas the virus persisted as long as 4 weeks on nonimpregnated materials. Viable vaccinia virus was also found to persist less than 1 day on a cotton fabric finished with a wash-and-wear modified triazone resin. Poliovirus persisted less than 5 days on this wash-and-wear fabric.