Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention
Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention
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DOI：
10.1016/j.ijcard.2016.04.050
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发表时间：
2016-08-01
影响因子：
3.5
通讯作者：
Olsson, Tommy
中科院分区：
文献类型：
--
作者：
Andersson, Jonas;Mellberg, Caroline;Olsson, Tommy
背景资料：心肌甘油三酯（MTG）蓄积与肥胖和糖尿病受试者左心室（LV）重构和功能受损相关。MTG蓄积在该组患者心力衰竭发生中的作用尚不清楚。短期研究表明，导致体重减轻的饮食可以动员MTG，对心脏重塑有有利的影响。在一项为期24个月的随机、双盲研究中，我们评估了两种不同饮食和随后的减肥对绝经后妇女心功能和MTG的影响。方法：68名体重指数（BMI）≥ 27 kg/m2的健康绝经后妇女被随机分配到随意旧石器时代饮食（PD）或北欧营养推荐（NNR）饮食组，为期24个月。在基线和6个月及24个月时，使用磁共振（MR）扫描（包括质子光谱）测量形态学、心脏功能和MTG水平。尽管平均体重减轻了4.9（1.0）kg（NNR）和7.8（1.1）kg（PD），MTG含量未随时间变化（24个月时，NNR组p = 0.98，PD组p = 0.11）。在24个月内，两个饮食组均观察到左心室质量降低。血压在6个月时降低，但在24个月时恢复到基线水平。舒张末期容积、每搏输出量和心输出量随时间降低。饮食组之间无差异observed.Conclusions：饮食干预和适度减肥超过24个月改善左心室重塑，但并没有改变MTG水平超重/肥胖绝经后妇女。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Background: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women.Methods: Sixty-eight healthy postmenopausal women with body mass index [BMI] >= 27 kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24 months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24 months.Results: Despite mean weight losses of 4.9 (1.0) kg (NNR) and 7.8 (1.1) kg (PD), the MTG content did not change over time (p = 0.98 in the NNR and p = 0.11 in the PD group at 24 months). Reduced left ventricular mass was observed in both diet groups over 24 months. Blood pressure was reduced at 6 months, but returned to baseline levels at 24 months. End diastolic volume, stroke volume, and cardiac output decreased over time. No differences between diet groups were observed.Conclusions: Diet intervention and moderate weight loss over 24 months improved LV remodelling but did not alter MTG levels in overweight/obese postmenopausal women. (C) 2016 Elsevier Ireland Ltd. All rights reserved.