Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
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DOI：
10.1038/s41598-020-66026-5
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发表时间：
2020-06-10
影响因子：
4.6
通讯作者：
Baker, Philip N.
中科院分区：
文献类型：
--
作者：
Chia, Ai-Ru;de Seymour, Jamie, V;Baker, Philip N.
婴儿肥胖可能与以后的代谢健康有关。母体代谢产物谱反映了遗传和环境的影响，并允许阐明与婴儿肥胖相关的代谢途径。在这个多种族的亚洲队列中，我们的目的是（i）确定与婴儿肥胖和其他出生结局相关的母体血浆代谢物，（ii）研究与这些代谢物相关的母体特征。在940对母子中，我们进行了气相色谱-质谱分析，并在妊娠26-28周的母体空腹血浆中鉴定了134种代谢物。出生时，新生儿三头肌和肩胛下皮褶厚度由训练有素的研究人员测量，而体重和长度的措施是从分娩记录中提取的。孕龄是通过妊娠早期的超声波测年来估计的。通过多变量线性回归评估相关性，使用Benjamini-Hochberg方法校正p值。在5%的错误发现率下，我们观察到28种代谢物与新生儿皮褶厚度总和之间的关联（13种氨基酸相关，4种非酯化脂肪酸，6种外源性物质和5种未知化合物）。几乎没有观察到与妊娠期、出生体重或出生身长的相关性。母亲的种族、孕前BMI和怀孕期间的饮食质量与婴儿肥胖相关的特定代谢组有最强的关联。进一步的研究是必要的，以复制我们的发现，并了解潜在的机制。
Infant adiposity may be related to later metabolic health. Maternal metabolite profiling reflects both genetic and environmental influences and allows elucidation of metabolic pathways associated with infant adiposity. In this multi-ethnic Asian cohort, we aimed to (i) identify maternal plasma metabolites associated with infant adiposity and other birth outcomes and (ii) investigate the maternal characteristics associated with those metabolites. In 940 mother-offspring pairs, we performed gas chromatography-mass spectrometry and identified 134 metabolites in maternal fasting plasma at 26-28 weeks of gestation. At birth, neonatal triceps and subscapular skinfold thicknesses were measured by trained research personnel, while weight and length measures were abstracted from delivery records. Gestational age was estimated from first-trimester dating ultrasound. Associations were assessed by multivariable linear regression, with p-values corrected using the Benjamini-Hochberg approach. At a false discovery rate of 5%, we observed associations between 28 metabolites and neonatal sum of skinfold thicknesses (13 amino acid-related, 4 non-esterified fatty acids, 6 xenobiotics, and 5 unknown compounds). Few associations were observed with gestational duration, birth weight, or birth length. Maternal ethnicity, pre-pregnancy BMI, and diet quality during pregnancy had the strongest associations with the specific metabolome related to infant adiposity. Further studies are warranted to replicate our findings and to understand the underlying mechanisms.