Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.
Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.
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DOI：
10.2147/ott.s130055
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发表时间：
2017
影响因子：
4
通讯作者：
Zhang G
中科院分区：
文献类型：
--
作者：
Feng S;Wang Y;Zhang R;Yang G;Liang Z;Wang Z;Zhang G
姜黄素是一种天然多酚类化合物，对多种癌症（包括鼻咽癌细胞）具有肿瘤抑制活性。然而，控制这种肿瘤抑制活性的确切分子机制仍然难以捉摸。多项研究表明，miRNAs在肿瘤发生中起着重要作用，这表明靶向miRNAs可能是治疗人类癌症的治疗策略。在目前的研究中，我们着手确定姜黄素是否调节鼻咽癌细胞中miR-7的表达。我们发现，姜黄素抑制细胞生长，诱导凋亡，延缓细胞迁移和侵袭，并触发细胞周期阻滞在人鼻咽癌细胞系CNE 1和CNE 2。重要的是，我们观察到姜黄素上调了miR-7的表达，随后抑制了Skp 2，一个直接的miR-7靶点。我们的研究结果表明，姜黄素上调miR-7可能对鼻咽癌患者有益。
Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. However, the exact molecular mechanisms governing this tumor suppressive activity remain elusive. Multiple studies have revealed that miRNAs are critically involved in tumorigenesis, indicating that targeting miRNAs could be a therapeutic strategy for treating human cancer. In the current study, we set out to determine whether curcumin regulates miR-7 expression in nasopharyngeal carcinoma cells. We found that curcumin inhibited cell growth, induced apoptosis, retarded cell migration and invasion, and triggered cell cycle arrest in the human nasopharyngeal carcinoma cell lines CNE1 and CNE2. Importantly, we observed that curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target. Our results identified that upregulation of miR-7 by curcumin could benefit nasopharyngeal carcinoma patients.