Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination
Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination
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DOI：
10.1016/j.plefa.2009.04.005
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发表时间：
2009-07-01
影响因子：
3
通讯作者：
Erkkila, Arja T.
中科院分区：
文献类型：
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作者：
Laasonen, Marja;Hokkanen, Laura;Erkkila, Arja T.
在DyAdd项目中，我们比较了注意缺陷多动障碍（ADHD）（n = 26），阅读障碍（n = 36），其共病组合（n = 9）和健康对照（n = 36）的成人血清磷脂的脂肪酸（FA）谱。采用Bonferroni校正的事后比较，在2 x 2设计中分析FA比例。使用问卷调查来评估膳食脂肪质量和补充剂的使用。结果表明，ADHD和阅读障碍与总饱和脂肪酸、单不饱和脂肪酸和n-3多不饱和脂肪酸（PUFAs）无关。然而，与没有ADHD的人相比，ADHD患者的总n-6 PUFA（包括γ-亚麻酸和肾上腺酸）的比例升高。阅读障碍与较高比例的单不饱和神经酸和较高比例的n-6/n-3 PUFA有关。在女性中，这些关联都不显著。然而，在男性中，在所有受试者中观察到的所有原始关联仍然存在，ADHD与神经酸和n-6/n-3 PUFA比值升高相关，如阅读障碍。控制诊断不佳的阅读困难、教育、膳食脂肪质量或使用FA补充剂通常不能消除最初观察到的相关性。(C)2009爱思唯尔有限公司保留所有权利。
In project DyAdd, we compared the fatty acid (FA) profiles of serum phospholipids in adults with attention deficit hyperactivity disorder (ADHD) (n = 26), dyslexia (n = 36), their comorbid combination (n = 9), and healthy controls (n = 36). FA proportions were analyzed in a 2 x 2 design with Bonferroni corrected post hoc comparisons. A questionnaire was used to assess dietary fat quality and use of Supplements. Results showed that ADHD and dyslexia were not associated with total saturated FAs, monounsaturated FAs, OF n-3 polyunsaturated FAs (PUFAs). However, those with ADHD had elevated Proportions of total n-6 PUFAs (including gamma-linolenic and adrenic acids) as compared to those without ADHD. Dyslexia was related to a higher proportion of monounsaturated nervonic acid and a higher ratio of n-6/n-3 PUFAs. Among females none of the associations were significant. However in males, all the original associations observed in all subjects remained and ADHD was associated with elevated nervonic acid and n-6/n-3 PUFA ratio like dyslexia. Controlling for poorly diagnosed reading difficulties, education, dietary fat quality, or use of FA supplements did not generally remove the originally observed associations. (C) 2009 Elsevier Ltd. All rights reserved.