Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest)
Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest)
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DOI：
10.1111/j.1469-1809.2008.00454.x
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发表时间：
2008-09-01
影响因子：
1.9
通讯作者：
Wang, Q. K.
中科院分区：
文献类型：
--
作者：
Abdullah, K. G.;Li, L.;Wang, Q. K.
全基因组关联研究分别发现了染色体9p21上的四个单核苷酸多态(SNPs)，它们与冠状动脉疾病(CAD)和心肌梗死(MI)的易感性有关。本研究首次在一个早产的家族性CAD/MI人群(GeneQuest)中分析了这些SNPs(rs10757274、rs2383206、rs2383207和rs10757278)。我们对GeneQuest高加索人群进行了病例对照分析，包括310例早产儿CAD和MI患者(发病时平均年龄为40.3+/-5.1岁)和560名非CAD对照人群，采用基于人群和基于家庭的关联研究设计，以确定这些SNP是否与CAD风险相关。在GeneQuest高加索人群中，这4个SNP与早产儿和家族性心肌梗死和冠心病显著相关(等位基因P=6.61×10(-7)~1.87×10(-8))。SIB-TDT分析表明，四个SNP中的三个可显著易感早产儿冠心病和心肌梗死。这些结果表明，染色体9p21上的4个SNPs也与早产儿、家族性冠心病相关。
Genome-wide association studies have separately identified four single nucleotide polymorphisms (SNPs) on chromosome 9p21 that confer susceptibility to coronary artery disease (CAD) and myocardial infarction (MI). This study presents the first analysis of these SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) in a premature, familial CAD/MI population (GeneQuest). We performed a case-control analysis of the GeneQuest Caucasian population with 310 cases with premature CAD and MI (average age at onset of 40.3 +/- 5.1) and 560 non-CAD controls to determine if these SNPs are associated with risk of CAD using both the population-based and family-based association study designs. The four SNPs are significantly associated with premature and familial MI and CAD in the GeneQuest Caucasian population (allelic P = 6.61 x 10(-7) to 1.87 x 10(-8)). Sib-TDT analysis showed that three of the four SNPs could confer significant susceptibility to premature CAD and MI. These results indicate that the four SNPs on chromosome 9p21 are also associated with premature, familial CAD.