Detection of Magnetic Nanoparticles with High T c SQUID and Application to Biological Immunoassays
Detection of Magnetic Nanoparticles with High T c SQUID and Application to Biological Immunoassays
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高T c SQUID 磁性纳米粒子检测及其在生物免疫分析中的应用
DOI：
10.1007/978-4-431-66877-0_306
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
K. Enpuku
中科院分区：
文献类型：
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作者：
T. Minotani;Takemitu Gima;K. Enpuku
研制了一种利用高Tc SQUID磁强计对生物抗原抗体反应进行磁测量的系统。在该系统中，抗体被直径为a=50 nm的γ-Fe 2 O3磁性纳米颗粒标记。通过检测磁性纳米颗粒的磁场来测量抗原抗体反应。目前，小至N =1.8 × 106（或600 pg）的磁性颗粒可以被检测到。随着本系统的复杂性，灵敏度的数量级改进将不是困难的。
A system is developed to magnetically measure biological antigen-antibody reactions with highTcSQUID magnetometer. In this system, antibodies are labeled with magnetic nanoparticles of γ-Fe2O3whose diameter is a=50 nm. The antigen-antibody reactions are measured by detecting the magnetic field from the magnetic nanoparticles. Magnetic particles as small asN=1.8 x106(or 600 pg) can be detected at present. An order of magnitude improvement of the sensitivity will not be difficult with the sophistication of the present system.