REMODELING OF CORONARY-ARTERIES IN HUMAN AND NONHUMAN-PRIMATES
REMODELING OF CORONARY-ARTERIES IN HUMAN AND NONHUMAN-PRIMATES
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DOI：
10.1001/jama.271.4.289
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发表时间：
1994-01-26
影响因子：
120.7
通讯作者：
KLEIN, KP
中科院分区：
文献类型：
--
作者：
CLARKSON, TB;PRICHARD, RW;KLEIN, KP
客观。-比较人和非人灵长类动物的冠状动脉重塑（代偿性扩张）。回顾性分析了416只非人类灵长类动物和100名男性和女性的冠状动脉数据。这些猴子曾参与过饮食诱导冠状动脉粥样硬化的实验。人类心脏来自北卡罗来纳州浸信会医院，温斯顿-塞勒姆，年龄大于25岁是唯一的标准。使用了来自100名人类、328只食蟹猴和88只雄性恒河猴的左前降支冠状动脉。无;这是一项横断面观察性研究。主要结果指标。冠状动脉大小、管腔面积和斑块大小。在人类中，我们还检查了人口统计学特征（种族，性别和高血压史）和病理学标准（斑块面积的偏心率或同心度）。平均而言，管腔大小不受斑块大小的影响。管腔大小是可变的，不能用传统的冠心病危险因素来预测。然而，缺乏代偿（随着斑块扩大，管腔尺寸减小）和冠心病病史显著相关。人类和非人类灵长类动物的重塑相似性表明，这一过程具有普遍的生物学意义。缺乏重塑可能是一个人是否与冠状动脉粥样硬化发展其并发症的主要决定因素。
Objective.-To compare coronary artery remodeling (compensatory enlargement) in human and nonhuman primates.Design.-Coronary artery data were analyzed retrospectively for 416 nonhuman primates and 100 men and women.Setting.-The monkeys had been in experiments involving diet-induced coronary artery atherosclerosis. The human hearts were obtained from the North Carolina Baptist Hospital, Winston-Salem, and age greater than 25 years was the only criterion.Patients and Other Participants.-The left anterior descending coronary arteries from 100 humans, 328 cynomolgus monkeys, and 88 male rhesus monkeys were used.Interventions.-None; this was a cross-sectional observational study.Main Outcome Measures.-Coronary artery size, lumen area, and plaque size. In the humans, we also examined demographic characteristics (ethnicity, sex, and history of hypertension) and pathologic criteria (eccentricity or concentricity of plaque area).Results.-On average, lumen size remained unaffected by plaque size. Lumen size was variable and could not be predicted by traditional risk factors for coronary heart disease. However, lack of compensation (decreased lumen size as plaques enlarged) and history of coronary heart disease were significantly correlated.Conclusions.-The similarity of remodeling in human and nonhuman primates suggests that the process has general biologic significance. Lack of remodeling may be a major determinant of whether a person with coronary artery atherosclerosis develops its complications.