Effect of Bubble Concentration on the in Vitro and in Vivo Performance of Highly Stable Lipid Shell-Stabilized Micro- and Nanoscale Ultrasound Contrast Agents
Effect of Bubble Concentration on the in Vitro and in Vivo Performance of Highly Stable Lipid Shell-Stabilized Micro- and Nanoscale Ultrasound Contrast Agents
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DOI：
10.1021/acs.langmuir.9b00462
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发表时间：
2019-08-06
期刊：
影响因子：
3.9
通讯作者：
Exner, Agata A.
中科院分区：
文献类型：
--
作者：
Abenojar, Eric C.;Nittayacharn, Pinunta;Exner, Agata A.
超声(US)是一种广泛使用的诊断成像工具，因为它便宜、安全、便携且可广泛使用。超声造影剂(UCAS)用于增强后向散射回波，提高成像对比度。最常用的UCA是由磷脂或蛋白质稳定的疏水气体核心制成的回声气泡。在临床应用时，UCA的应用往往受到快速信号衰减(
Ultrasound (US) is a widely used diagnostic imaging tool because it is inexpensive, safe, portable, and broadly accessible. Ultrasound contrast agents (UCAs) are employed to enhance backscatter echo and improve imaging contrast. The most frequently utilized UCAs are echogenic bubbles made with a phospholipid or protein-stabilized hydrophobic gas core. While clinically utilized, applications of UCAs are often limited by rapid signal decay (