Prolonged, Uninterrupted Sedentary Behavior and Glycemic Biomarkers Among US Hispanic/Latino Adults: The HCHS/SOL (Hispanic Community Health Study/Study of Latinos).
Prolonged, Uninterrupted Sedentary Behavior and Glycemic Biomarkers Among US Hispanic/Latino Adults: The HCHS/SOL (Hispanic Community Health Study/Study of Latinos).
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DOI：
10.1161/circulationaha.116.026858
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发表时间：
2017-10-10
期刊：
影响因子：
37.8
通讯作者：
Kaplan RC
中科院分区：
文献类型：
--
作者：
Diaz KM;Goldsmith J;Greenlee H;Strizich G;Qi Q;Mossavar-Rahmani Y;Vidot DC;Buelna C;Brintz CE;Elfassy T;Gallo LC;Daviglus ML;Sotres-Alvarez D;Kaplan RC
久坐时间过长在发达国家普遍存在，并与有害的健康后果有关。很少有研究检验久坐时间累积的方式(短时间或长时间)是否与临床相关。这项研究的目的是在一组美国拉美裔/拉丁裔成年人中检查长期不受干扰的久坐行为与血糖生物标志物的关系。我们研究了12,083名来自西班牙裔社区健康研究/拉丁裔研究(HCHS/SOL)的参与者，这是一项基于人群的研究，对18-74岁的拉美裔/拉丁裔成年人进行了研究。胰岛素抵抗的稳态模型评估(HOMA-IR)和糖化血红蛋白(Hb1Ac)从空腹血样中测量，并在口服葡萄糖耐量试验后测量2小时血糖。使用髋部安装的加速度计客观地测量坐着的时间。延长的、不间断的久坐时间表示为平均久坐时间。调整了潜在的混杂因素和中等强度的体力活动后，久坐不动的比赛时间较长与HOMA-IR(p-趋势和lt；0.001)和2小时血糖水平(p-趋势=0.015)的增加呈剂量依赖性相关。这些关联并不独立于总的久坐时间，然而，在久坐时间和总的久坐时间之间观察到了显著的交互作用。对总久坐时间和久坐时间的联合评估表明，在两种久坐特征(即总久坐时间长和久坐时间长)的高四分位数的参与者中，HOMA-IR水平最高(p<；0.001对低坐特性组)和2小时血糖水平(p=0.002对低久坐特性组)。高总久坐时间或长时间久坐本身与任何血糖生物标志物的差异无关，长时间、不间断的久坐可能与血糖调节的生物标志物有害相关。
Excessive sedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Few studies have examined whether the manner in which sedentary time is accrued (in short or long bouts) carries any clinical relevance. The purpose of this study was to examine the association of prolonged-uninterrupted sedentary behavior with glycemic biomarkers in a cohort of U.S. Hispanic/Latino adults. We studied 12,083 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a population-based study of Hispanic/Latino adults 18–74 years. Homeostatic model assessment of insulin resistance (HOMA-IR) and glycosylated hemoglobin (Hb1Ac) were measured from a fasting blood sample and 2-hour glucose was measured following an oral glucose tolerance test. Sedentary time was objectively measured using a hip-mounted accelerometer. Prolonged, uninterrupted sedentariness was expressed as mean sedentary bout length. Adjusted for potential confounders and moderate-vigorous physical activity, longer sedentary bout duration was dose-dependently associated with increased HOMA-IR (p-trend <0.001) and 2-hour glucose levels (p-trend=0.015). These associations were not independent of total sedentary time, however a significant interaction between sedentary bout duration and total sedentary time was observed. Evaluation of the joint association of total sedentary time and sedentary bout duration showed that participants in the upper quartile for both sedentary characteristics (i.e. high total sedentary time and high sedentary bout duration) had the highest levels of HOMA-IR (p<0.001 vs. low group for both sedentary characteristics) and 2-hour glucose (p=0.002 vs. low group for both sedentary characteristics). High total sedentary time or high sedentary bout duration alone were not associated with differences in any glycemic biomarkers Accruing sedentary time in prolonged, uninterrupted bouts may be deleteriously associated with biomarkers of glucose regulation.