Synthesis of Mesoporous Calcium Phosphate Microspheres by Chemical Transformation Process: Their Stability and Encapsulation of Carboxymethyl Chitosan
Synthesis of Mesoporous Calcium Phosphate Microspheres by Chemical Transformation Process: Their Stability and Encapsulation of Carboxymethyl Chitosan
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DOI：
10.1021/cg400595s
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发表时间：
2013-06
影响因子：
3.8
通讯作者：
Cong Sui;Yang Lu;Huailing Gao;L. Dong;Yang Zhao;L. Ouali;D. Benczédi;H. Jerri;Shuhong Yu-
中科院分区：
文献类型：
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作者：
Cong Sui;Yang Lu;Huailing Gao;L. Dong;Yang Zhao;L. Ouali;D. Benczédi;H. Jerri;Shuhong Yu-
我们报告了碳酸钙微粒（CCM）转化为磷酸钙微粒（CPM）与调制的形态和相位。在这种无添加剂的转化过程中，避免了模板或表面活性剂的使用，从而消除了最终产品的潜在污染。高收率的羟基碳酸磷灰石（HCAP）微球在水溶液中比CaCO3微球更稳定，具有更高的比表面积，表明其具有比CaCO3更高的负载能力。此外，产品具有良好的生物相容性，因为它们不含外来表面活性剂或稳定剂，因此不需要进一步纯化。为了考察微球的载药效率，以优良的生物医用材料羧甲基壳聚糖（CMC）和阿霉素分别作为模型高分子量和低分子量探针，考察了微球的包封率。
We report on the transformation of calcium carbonate microparticles (CCMs) to calcium phosphate microparticles (CPMs) with modulated morphologies and phases. In this additive-free transformation process, the use of templates or surfactants was circumvented, thereby eliminating potential contamination of the final products. The hydroxycarbonate apatite (HCAP) microspheres in high yield were more stable than CaCO3 microspheres in aqueous solution and had higher specific surface areas, which suggested that they had higher loading capability than their CaCO3 counterpart. In addition, the products had good biocompatibility because they were free from extraneous surfactants or stabilizers and, hence, did not require further purification. In order to examine the loading efficiency of these microspheres, carboxymethyl chitosan (CMC) and doxorubicin, which were both excellent biomedical materials, were taken as model high molecular weight and low molecular weight probes, respectively, to investigate the encapsulat...