Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.
Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.
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DOI：
10.1053/j.gastro.2017.07.041
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发表时间：
2018-01
期刊：
影响因子：
29.4
通讯作者：
Fitzgerald RC
中科院分区：
文献类型：
--
作者：
di Pietro M;Canto MI;Fitzgerald RC
食管癌的早期诊断和治疗是有可能的，因为食管很容易通过内镜检查。然而，由于早期症状非特异性，吞咽困难的发作与疾病晚期相关，因此诊断往往被延迟，后者的5年生存率低于15%。通过内窥镜进行大规模筛查不具有成本效益，因此正在研究一些替代成像和细胞取样技术。理想的筛查试验需要价格低廉，耐受性好，并适用于初级保健。在过去的10年里，在内镜下诊断和治疗不典型增生（鳞状和巴雷特）和早期食管癌方面取得了重大进展，使用切除和消融技术得到了随机对照试验证据的支持。在这里，我们回顾了早期诊断和微创治疗的最新技术，它们共同具有减轻疾病负担的潜力。
Since the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are non-specific in the early stages and the onset of dysphagia is associated with advanced disease, which has a 5-year survival of less of 15%. Mass screening by endoscopy is not cost-effective, hence a number of alternative imaging and cell sampling technologies are under investigation. The ideal screening test needs to be inexpensive, well tolerated and applicable to primary care. Over the last 10 years, significant progress has been made in the endoscopic diagnosis and treatment of dysplasia (squamous and Barrett’s) and early esophageal cancer using resection and ablation technologies supported by evidence from randomised controlled trials. Here we review the state-of-the-art technologies for early diagnosis and minimally invasive treatment, which together have the potential to reduce the burden of disease.
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影响因子：
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