CHD proteins: a diverse family with strong ties
CHD proteins: a diverse family with strong ties
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DOI：
10.1139/o07-063
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发表时间：
2007-08-01
期刊：
影响因子：
--
通讯作者：
Georgel, Philippe T.
中科院分区：
文献类型：
--
作者：
Hall, J. Adam;Georgel, Philippe T.
Chromodomain/helicase/DNA-binding domain (CHD) proteins have been identified in a variety of organisms. Despite common features, such as their chromodomain and helicase domain, they have been described as having multiple roles and interacting partners. However, a common theme for the main role of CHD proteins appears to be linked to their ATP-dependent chromatin-remodeling activity. Their actual activity as either repressor or activator, and their cell or gene specificity, is connected to their interacting partner(s). In this minireview, we attempt to match the members of the CHD family with the presence of structural domains, cofactors, and cellular roles in the regulation of gene expression, recombination, genome organization, and chromatin structure, as well as their potential activity in RNA processing.
