Molecular cloning of a novel Xenopus spalt gene (Xsal-3)
Molecular cloning of a novel Xenopus spalt gene (Xsal-3)
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DOI：
10.1006/bbrc.1999.1479
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发表时间：
1999-10-14
影响因子：
3.1
通讯作者：
Asashima, M
中科院分区：
文献类型：
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作者：
Onuma, Y;Nishinakamura, R;Asashima, M
sal（spalt）基因家族的特征在于独特的双锌指基序，并且在从果蝇到人类的各种物种中是保守的。在这里，我们报告一个新的爪蟾成员，Xsal-3。它是38%的同源性，在氨基酸水平上，以先前报道的爪蟾同源的spalt基因，Xsal-1。选择性剪接的Xsal-3转录物产生编码两个或三个双锌指的RNA，并且较长的形式在母体中表达。Xsal-3在神经管、下颌骨、舌骨和鳃弓以及前肾管中表达，这与Xsal-1的表达模式不同。这些发现表明，Xsal-3可能在早期爪蟾发育中具有独特的作用，（C）1999年学术出版社。
The sal (spalt) gene family is characterized by unique double zinc finger motifs and is conserved among various species from Drosophila to humans. Here we report a new Xenopus member of this family, Xsal-3. It is 38% homologous at the amino acid level to the previously reported Xenopus homologue of the spalt gene, Xsal-1. Alternatively spliced Xsal-3 transcripts give rise to RNAs coding either two or three double zinc fingers, and the longer form is expressed maternally. Xsal-3 is expressed in the neural tube, the mandibular, hyoid, and branchial arch, and the pronephric duct, which is different from the expression pattern of Xsal-1. These findings suggest that Xsal-3 may have distinct roles in early Xenopus development, (C) 1999 Academic Press.