Plasma ALP activity and blood PCV value changes in chick fetuses due to exposure of the egg to different xenobiotics.
Plasma ALP activity and blood PCV value changes in chick fetuses due to exposure of the egg to different xenobiotics.
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由于鸡蛋暴露于不同的外源物质，鸡胎儿的血浆 ALP 活性和血液 PCV 值发生变化。
DOI：
10.1016/s0269-7491(01)00179-8
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发表时间：
2002
影响因子：
8.9
通讯作者：
I. Hlubik
中科院分区：
文献类型：
--
作者：
V. Kertész;I. Hlubik
研究了两种多环芳烃（PAH）化合物（苯(k)氟蒽和氟蒽）和两种重金属（镉和铅）对鸡胎儿碱性磷酸酶（ALP）酶活性和红细胞压积（PCV）值的影响。鸡蛋在孵育前暴露于四种化合物中的一种，采用两种暴露方法：注射（进入空气池）或浸泡。与对照组相比，氟蒽、镉和铅注射显著降低了ALP活性，而浸泡组的ALP活性均未显著降低；然而，在这些群体中也有下降的趋势。本茨(k)荧光蒽浸泡、荧光蒽浸泡和注射镉后红细胞压积值升高。然而，本研究中的剂量相对较低（与其他鸟类生态毒理学研究相比），每个治疗组的ALP酶活性和PCV值的变化都很明显，这表明鸡胎儿对该药物高度敏感。
The effects of two polycyclic aromatic hydrocarbon (PAH) compounds (benz(k)fluoranthene and fluoranthene) and two heavy metals (cadmium and lead) were studied on the alkaline phosphatase (ALP) enzyme activity and hematocrit (PCV) values in chick fetuses. Eggs were exposed to one of the four compounds before incubation, by applying two exposure methods: injection (into the air cell) or immersion. Fluoranthene, cadmium and lead injection significantly decreased ALP activity compared to the control, while none of the compounds caused significant reduction in ALP activity in the immersion groups; however, a decreasing tendency was seen in these groups as well. Hematocrit values were increased after benz(k)fluoranthene immersion, fluoranthene immersion and cadmium injection. However, the doses in this study are relatively low (compared to other ecotoxicological studies in birds), the alteration in ALP enzyme activity and PCV values was apparent in each treatment group and is indicative of the high sensitivity of chick fetuses.