Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes.
Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes.
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DOI：
10.1186/s41232-021-00156-9
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发表时间：
2021-02-01
影响因子：
8.1
通讯作者：
Fukuda K
中科院分区：
文献类型：
--
作者：
Tanosaki S;Tohyama S;Kishino Y;Fujita J;Fukuda K
多能干细胞（Pluripotent stem cells，PSC）在再生治疗、药物研发和疾病建模等方面具有广阔的应用前景。虽然存在几种用于从PSC分化体细胞的方案，但它们的使用受到残留未分化PSC的污染和分化体细胞的不成熟的限制。PSC的代谢与体细胞的代谢有很大不同，并且需要一个独特的特征来维持PSC的独特性质。迄今为止，已有几项研究报道了PSC及其衍生细胞中代谢的重要性。在这里，我们详细介绍了该领域的进展，重点是心脏再生治疗。
Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells. The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.
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影响因子：
20.1
作者：
Feaster TK;Cadar AG;Wang L;Williams CH;Chun YW;Hempel JE;Bloodworth N;Merryman WD;Lim CC;Wu JC;Knollmann BC;Hong CC
通讯作者：
Hong CC
DOI：
10.1016/j.biocel.2007.11.009
发表时间：
2008-01-01
影响因子：
4
作者：
Lee, Jungwoon;Kim, Hye Kyoung;Kim, Jungho
通讯作者：
Kim, Jungho
影响因子：
29
作者：
Hwang, In-Young;Kwak, Sojung;Youn, Hong-Duk
通讯作者：
Youn, Hong-Duk
影响因子：
4.3
作者：
Constable, Sandii;Lim, Jae-Min;Wells, Lance
通讯作者：
Wells, Lance
影响因子：
29
作者：
Folmes CD;Nelson TJ;Martinez-Fernandez A;Arrell DK;Lindor JZ;Dzeja PP;Ikeda Y;Perez-Terzic C;Terzic A
通讯作者：
Terzic A