INTERACTIONS BETWEEN CD4+ T-CELLS AND RAT SCHWANN-CELLS INVITRO .2. CYTOTOXIC EFFECTS OF P2-SPECIFIC CD4+ T-CELL LINES ON LEWIS RAT SCHWANN-CELLS
INTERACTIONS BETWEEN CD4+ T-CELLS AND RAT SCHWANN-CELLS INVITRO .2. CYTOTOXIC EFFECTS OF P2-SPECIFIC CD4+ T-CELL LINES ON LEWIS RAT SCHWANN-CELLS
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DOI：
10.1016/0165-5728(92)90209-4
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发表时间：
1992-09-01
影响因子：
3.3
通讯作者：
BONNER, J
中科院分区：
文献类型：
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作者：
ARGALL, KG;ARMATI, PJ;BONNER, J
用Cr-51释放细胞毒性试验在体外检测CD 4 + P2特异性T细胞系对雪旺细胞的细胞毒性作用。只有那些能够诱导EAN的P2特异性T细胞系，当注射回成年刘易斯大鼠时，对雪旺细胞具有细胞毒性。外源性P2蛋白的加入不是产生细胞毒作用的必要条件。针对主要组织相容性复合体（MHC）II类分子的单克隆抗体（mAb）OX 6阻断细胞毒性，表明MHC II类分子在CD 4 + T细胞系和许旺细胞之间的相互作用中发挥重要作用。
The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with Cr-51-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not necessary for the cytotoxic effect. The monoclonal antibody (mAb) OX6 directed against Major histocompatibility complex (MHC) class II molecules blocked cytotoxicity, indicating an essential role for MHC class II molecules in this interaction between CD4+ T-cell lines and Schwann cells.