Relation of ABO blood groups to the severity of coronary atherosclerosis: An Gensini score assessment
Relation of ABO blood groups to the severity of coronary atherosclerosis: An Gensini score assessment
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DOI：
10.1016/j.atherosclerosis.2014.10.107
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发表时间：
2014-12-01
期刊：
影响因子：
5.3
通讯作者：
Li, Jian-Jun
中科院分区：
文献类型：
--
作者：
Gong, Ping;Luo, Song-Hui;Li, Jian-Jun
目的：虽然关于ABO血型与冠状动脉粥样硬化关系的研究由来已久，但在大的队列研究中，ABO血型与冠状动脉粥样硬化严重程度的相关数据很少。因此，本研究旨在探讨ABO血型与冠状动脉粥样硬化严重程度的关系，用Gensini评分（GS）评估中国大型冠状动脉造影队列。方法：收集连续2919例接受冠状动脉造影的患者的基线特征和ABO血型。根据血管造影结果计算GS为1分位数（0-10）、2分位数（11-36）、3分位数（> -36）。探讨ABO血型与GS的关系。结果：A型血的出现频率在GS上三分位数明显较高（24.4%比28.2%比29.5%,p = 0.032）。多变量线性回归分析显示，A血型与GS独立相关（β = 0.043, p = 0.017）。同样，多变量logistic回归分析显示，A组仍与中高GS显著相关（OR = 1.44, 95% CI 1.16-1.80, p = 0.001），而O组显示为保护因素（OR = 0.77, 95% CI = 0.65-0.92, p = 0.004）。结论：在这项大型中国队列研究中，数据表明ABO血型与冠状动脉粥样硬化严重程度之间存在关联。此外，A型血是严重冠状动脉粥样硬化的独立危险因素。2014爱思唯尔爱尔兰有限公司版权所有。
Objective: Although the study on the relationship between ABO blood groups and coronary atherosclerosis has a long history, few data is available regarding ABO to severity of coronary atherosclerosis in a large cohort study. Therefore, the present study aimed to investigate the relation of the ABO blood groups to the severity of coronary atherosclerosis assessed by Gensini score (GS) in a large Chinese cohort undergoing coronary angiography. Methods: A total of 2919 consecutive patients undergoing coronary angiography were enrolled, and their baseline characteristics and ABO blood groups were collected. The GS was calculated as 1st tertile (0-10), 2nd tertile (11-36), 3rd tertile (>36) according to angiographic results. The relation of the ABO blood groups to GS was investigated. Results: The frequency of blood group A was significantly higher in the upper GS tertiles (24.4% vs. 28.2% vs. 29.5%, p = 0.032). Multivariable linear regression analysis revealed that blood group A was independently associated with GS (beta = 0.043, p = 0.017). Likewise, multivariable logistic regression analysis showed that group A remained significantly associated with mid-high GS (OR = 1.44, 95% CI 1.16-1.80, p = 0.001), and the group O was showed as a protective factor (OR = 0.77, 95% CI = 0.65-0.92, p = 0.004). Conclusion: In this large Chinese cohort study, the data indicated that there was an association between ABO blood groups and the severity of coronary atherosclerosis. Moreover, the blood group A was an independent risk factor for serious coronary atherosclerosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.