Acute kidney injury. Protective role of gut microbial SCFAs.
Acute kidney injury. Protective role of gut microbial SCFAs.
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DOI：
10.1038/nrneph.2015.10
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发表时间：
2015-03-01
期刊：
影响因子：
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通讯作者：
Carney, Ellen F
中科院分区：
文献类型：
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作者：
Carney, Ellen F
用产乙酸盐细菌处理的小鼠在其血浆和粪便中具有增加的乙酸盐水平，并且与未处理的对照相比对肾缺血再灌注损伤较不敏感。Câmara说：“醋酸盐可以减少全身和肾组织的炎症，调节免疫细胞活化，减少肾上皮细胞的缺氧，这很可能是通过表观遗传机制实现的。”“我们正在进行的实验已经显示出SCFA在脓毒症和慢性损伤模型中的有希望的结果。除了有希望的阿基管理工具外，我们认为SCFA可能对脓毒症患者和已故供体肾移植期间使用的保存液有益，以降低移植物功能延迟的风险。
mice treated with acetate-producing bacteria had increased levels of acetate in their plasma and faeces and were less susceptible to renal ischaemia–reperfusion injury than were untreated controls.“Acetate reduces inflammation systemically and in renal tissue, regulates immune cell activation and reduces hypoxia in kidney epithelial cells, most likely via epigenetic mechanisms,” says Câmara.“Our ongoing experiments have shown promising results with SCFAs in sepsis and chronic injury models. As well as promising tools for the management of AKI, we believe that SCFAs might be beneficial in patients with sepsis and in preservation solutions used during deceased donor kidney transplantation to reduce the risk of delayed graft function.”