SARS-CoV-2 vaccines-induced thrombotic thrombocytopenia: should we consider immuno-hypersensitivity?
SARS-CoV-2 vaccines-induced thrombotic thrombocytopenia: should we consider immuno-hypersensitivity?
复制标题
SARS-COV-2疫苗诱导的血小板减少症：我们应该考虑免疫 - 高敏感性吗？
DOI：
10.11606/s1518-8787.2021055003855
复制
发表时间：
2021
影响因子：
2.8
通讯作者：
Adogo LY
中科院分区：
文献类型：
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作者：
Reuben RC;Adogo LY
2019 年冠状病毒病 (COVID-19) 大流行正在全球范围内造成前所未有的临床、社会经济和公共卫生挑战。人们普遍认为，全球成功管理有效、安全和可持续的疫苗对于缓解和预防 COVID-19 至关重要。然而，COVID-19 疫苗免疫后严重不良事件 (AEFI) 的病例不断增加，包括血栓形成、血小板减少，甚至在某些情况下甚至死亡，已引起全球严重关注，并可能极大地导致人们对疫苗犹豫不决。尽管与 AEFI 相关的 COVID-19 疫苗的完整基础病理生理学和免疫病理学（包括血栓形成和/或过敏反应）尚未确定，但探索可能的免疫超敏反应可能对于与这些反应相关的机制至关重要，从而减少其发生并恢复对疫苗接种的信心，以建立一个没有 COVID-19 的世界。
The coronavirus disease 2019 (COVID-19) pandemic is significantly causing unprecedented clinical, socioeconomic, and public health challenges globally. The successful global administration of effective, safe and sustainable vaccine(s) is widely believed to be crucial in mitigating as well as preventing COVID-19. However, the rising cases of severe adverse events following immunization (AEFI) with COVID-19 vaccines including thrombosis, thrombocytopenia, and in some instances, death have created serious global concerns and could enormously contribute to vaccine hesitancy. Although the complete underlying pathophysiology and immunopathology of the COVID-19 vaccines related to AEFI, including thrombosis and/or anaphylaxis, are yet to be determined, exploring possible immuno-hypersensitivity could be crucial in the mechanisms associated with these reactions, thereby mitigating their occurrences as well as restoring confidence in vaccine administration for a COVID-19 free world.
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DOI：
10.1056/nejmoa2104840
发表时间：
2021-06-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Greinacher A;Thiele T;Warkentin TE;Weisser K;Kyrle PA;Eichinger S
通讯作者：
Eichinger S
影响因子：
2.6
作者：
Laplante, P.;Fuentes, R.;Rauch, J.
通讯作者：
Rauch, J.
影响因子：
3.3
作者：
Moulis, Guillaume;Sommet, Agnes;Montastruc, Jean-Louis
通讯作者：
Montastruc, Jean-Louis
影响因子：
5.7
作者：
Levi, Marcel;van der Poll, Tom
通讯作者：
van der Poll, Tom
影响因子：
3.6
作者：
Da Dalt, Liviana;Zerbinati, Claudia;Menniti-Ippolito, Francesca
通讯作者：
Menniti-Ippolito, Francesca