Zinc and copper balances in preterm infants.
Zinc and copper balances in preterm infants.
复制标题
早产儿的锌和铜平衡。
DOI：
10.1542/peds.77.4.513
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发表时间：
1986
期刊：
影响因子：
8
通讯作者：
E. Tyrala
中科院分区：
文献类型：
--
作者：
E. Tyrala
如果在出生后没有以生物可利用的形式提供足量的铜和锌营养素，早产儿就有铜和锌枯竭的风险。本研究的目的是确定是否使用乳清为主，50%中链甘油三酯配方奶粉与相对高浓度的锌和铜会促进早产儿实现锌和铜的宫内增积率。两组五名早产儿被喂食含有12.5毫克/升锌和0.9毫克/升或2.1毫克/升铜的饮食。72小时的代谢平衡研究在平均孕后年龄34周，平均体重1549克时进行。所有婴儿均处于锌平衡阳性状态，其中9 / 10达到34周妊娠胎儿的子宫内锌吸积率（大于或等于0.432 mg/d）。3名接受高铜配方奶粉的婴儿和2名接受低铜配方奶粉的婴儿铜正平衡。两组均有两名婴儿达到孕34周胎儿的子宫内铜吸积率（0.088 mg/d）。一个提供12.5毫克/升锌的配方允许正锌平衡和锌潴留类似于子宫内的速率。然而，一个提供高达2.1毫克/升铜的配方可能并不总是允许铜的正平衡。
Preterm infants are at risk for copper and zinc depletion if sufficient quantities of these nutrients are not provided in a bioavailable form in postnatal life. The purpose of this study was to determine whether the use of a whey-predominant, 50% medium chain triglyceride formula with relatively high concentrations of zinc and copper would promote the achievement of the in utero accretion rate for zinc and copper in the preterm infant. Two groups of five preterm infants were fed a diet containing 12.5 mg/L of zinc and either 0.9 mg/L or 2.1 mg/L of copper. Seventy-two-hour metabolic balance studies were performed at an average postconceptual age of 34 weeks and an average weight of 1,549 g. All infants were in positive zinc balance and nine of ten achieved the in utero accretion rate for zinc for a 34-week gestation fetus (greater than or equal to 0.432 mg/d). Three infants receiving the high copper formula and two receiving the lower copper formula were in positive copper balance. Two infants from each group achieved the in utero accretion rate for copper for a 34-week gestation fetus (0.088 mg/d). A formula that provides 12.5 mg/L of zinc permits positive zinc balance and zinc retention similar to in utero rates. A formula that provides as much as 2.1 mg/L of copper, however, may not always permit positive copper balance.