Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee.
Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee.
复制标题
氨基葡萄糖治疗膝骨关节炎的随机对照试验。
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
Greg Arriola
中科院分区：
文献类型：
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作者：
J. Rindone;D. Hiller;E. A. Collacott;N. Nordhaugen;Greg Arriola
目的
确定氨基葡萄糖在减轻膝关节骨关节炎疼痛方面的有效性。
设计
氨基葡萄糖500 mg每日3次或安慰剂治疗2个月的随机、双盲平行试验。
设置
退伍军人事务医疗中心，普雷斯科特，亚利桑那州。
参与者
98名年龄在34 - 81岁的患者接受膝关节骨关节炎治疗。
主要观察指标
在基线和治疗30天和60天后，通过视觉模拟量表评估静息和行走时的疼痛强度。
结果
49名患者被随机分配到每组。两组在休息30天时的视觉模拟量表评分无统计学差异（安慰剂组平均[SD]评分3.5 [2.7] vs葡萄糖胺组3.3 [2.4]，P = 0.66）或步行（5.1 [2.6] vs 5.3 [2.4]，P = 0.69）;在60天时，休息（3.4 [2.5] vs 3.2 [2.5]，P = 0.81）或行走（4.9 [2.2] vs 4.9 [2.8]，P = 0.90）也没有差异。两组之间视觉模拟量表评分较基线的平均变化也无统计学差异（安慰剂组60天时行走的平均[SD]变化-1.5 [2.5] vs葡萄糖胺组-1.4 [3.0]，P = 0.77）。两名服用葡萄糖胺的参与者和4名服用安慰剂的参与者由于不良副作用而退出研究（P = 0.67）。
结论
在这组患者中，氨基葡萄糖在减轻膝关节骨关节炎疼痛方面并不比安慰剂好。
OBJECTIVE
To determine the effectiveness of glucosamine in reducing pain from osteoarthritis of the knee.
DESIGN
Randomized, double-blind parallel trial of glucosamine 500 mg three times daily or a placebo for 2 months.
SETTING
Veterans Affairs Medical Center, Prescott, AZ.
PARTICIPANTS
Ninety-eight patients aged 34 to 81 being treated for osteoarthritis of the knee.
MAIN OUTCOME MEASURES
Pain intensity both at rest and while walking as assessed by a visual analog scale at baseline and after 30 and 60 days of treatment.
RESULTS
Forty-nine patients were randomly allocated to each group. There was no statistical difference between the two groups in scores on the visual analog scale at 30 days for resting (mean [SD] score placebo group 3.5 [2.7] vs 3.3 [2.4] glucosamine group, P = 0.66) or walking (5.1 [2.6] vs 5.3 [2.4], P = 0.69); there was also no difference at 60 days for resting (3.4 [2.5] vs 3.2 [2.5], P = 0.81) or walking (4.9 [2.2] vs 4.9 [2.8], P = 0.90). There was also no statistical difference between groups in the mean change from baseline in scores on the visual analog scale (mean [SD] change for walking at 60 days placebo group -1.5 [2.5] vs glucosamine group -1.4 [3.0], P = 0.77). Two participants taking glucosamine and 4 taking placebo withdrew from the study due to adverse side effects (P = 0.67).
CONCLUSION
Glucosamine was no better than placebo in reducing pain from osteoarthritis of the knee in this group of patients.
影响因子：
7
作者：
Uebelhart, D;Thonar, EJMA;Vignon, E
通讯作者：
Vignon, E