ADIPOSE-TISSUE IN THE MAMMALIAN HEART AND PERICARDIUM - STRUCTURE, FETAL DEVELOPMENT AND BIOCHEMICAL-PROPERTIES
ADIPOSE-TISSUE IN THE MAMMALIAN HEART AND PERICARDIUM - STRUCTURE, FETAL DEVELOPMENT AND BIOCHEMICAL-PROPERTIES
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DOI：
10.1016/0305-0491(89)90337-4
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发表时间：
1989-01-01
影响因子：
2.2
通讯作者：
POND, CM
中科院分区：
文献类型：
--
作者：
MARCHINGTON, JM;MATTACKS, CA;POND, CM
1. 本文综述了野生和家养哺乳动物心脏周围和心包膜脂肪组织的发生和相对丰度，并报道了一些新的数据。2. 对于猕猴和许多其他成年哺乳动物来说，心外膜脂肪细胞的平均体积恒定在其他储存库的平均体积的一半左右，尽管这个储存库的相对质量与身体其他部位脂肪组织的丰度无关。3. 在年轻成年豚鼠中，心外膜脂肪组织中脂肪酸的最大合成速率明显高于心包、肾周和腘窝脂肪库。4. 心外膜脂肪组织释放脂肪酸的速度大约是心包和肾周脂肪组织的两倍。5. 豚鼠心外膜和心包脂肪组织的蛋白质含量相似，且显著高于肾周和腘窝脂肪组织，线粒体丰度无部位特异性差异。6. 在成年猕猴中，心外膜脂肪组织利用葡萄糖的能力约为腹内脂肪组织的一半。7. 心外膜脂肪组织与身体其他部位脂肪组织的主要区别在于其更大的脂肪酸释放能力。8. 这表明，心脏脂肪组织可能作为邻近心肌的局部能量供应和/或作为对有毒水平的游离脂肪酸的缓冲。
1. The occurrence and relative abundance of adipose tissue around the heart and in the pericardium of wild and domesticated mammals are reviewed and some new data reported. 2. For macaque monkeys and a wide range of other adult mammals, the mean volume of epicardial adipocytes is constant at about half the average of that of other depots, although the relative mass of this depot is unrelated to the abundance of adipose tissue in the rest of the body. 3. In young adult guinea-pigs, the maximum rate of fatty acid synthesis is significantly higher in epicardial adipose tissue than that in the pericardial, perirenal and popliteal depots. 4. The rate of fatty acid release by epicardial adipose tissue is approximately twice that of the pericardial and perirenal depots. 5. The protein contents of guinea-pig epicardial and pericardial adipose tissue are similar, and are significantly higher than those of the perirenal and popliteal adipose tissue and there are no site-specific differences in the abundance of mitochondria. 6. In adult Macaca monkeys, the capacity of the epicardial adipose tissue for glucose utilization is about half that of the intra-abdominal depots. 7. The principal difference between epicardial adipose tissue and that elsewhere in the body is its greater capacity for fatty acid release. 8. It is suggested that cardiac adipose tissue may act as a local energy supply for adjacent myocardium and/or as a buffer against toxic levels of free fatty acids.