Quantifying Glaucoma Medication Adherence: The Relationship Between Self-Report, Electronic Monitoring, and Pharmacy Refill
Quantifying Glaucoma Medication Adherence: The Relationship Between Self-Report, Electronic Monitoring, and Pharmacy Refill
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DOI：
10.1089/jop.2015.0102
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发表时间：
2016-07-01
影响因子：
2.3
通讯作者：
Muir, Kelly W.
中科院分区：
文献类型：
--
作者：
Kumar, Jaya B.;Bosworth, Hayden B.;Muir, Kelly W.
目的：青光眼药物可降低进行性视野丧失的风险，但这些药物的依从性往往较差。需要更好地理解量化青光眼药物依从性的适当指标。我们描述和比较不同的手段量化青光眼药物adherence.Methods：成人青光眼患者参加了一项前瞻性的2-site研究。参与者完成了一个自我报告工具，并收到了电子药物监测器，使用了大约3个月。药房记录询问有关要求在监测期间的再填充;药物占有率（MPR）calculated.Results：的137总参与者，那些谁回答“非常自信”的问题，“有多少信心是你，你总是记得使用你的青光眼药物？而对于“在过去的4周里，你有没有忘记吃药？”根据电子药物监测器，“更有可能[比值比（OR）2.78，95%置信区间（CI）1.19-6.52]服用≥ 80%的处方剂量。平均MPR为1.49，标准差（SD）为0.82，范围为0.1-5.31。参与者的比例采取大于或等于80%的处方剂量，根据电子监视器是59%的参与者与MPR 1.8（n = 25）。结论：询问信心可能是一个很好的方法筛选依从性差的青光眼药物治疗。MPR可能不能充分反映青光眼药物治疗依从性。
Purpose: Glaucoma medications reduce the risk of progressive visual field loss, but adherence to these medications is often poor. A better understanding of the appropriate metrics for quantifying glaucoma medication adherence is needed. We describe and compare different means of quantifying glaucoma medication adherence.Methods: Adults with glaucoma were enrolled in a prospective 2-site study. Participants completed a self-report instrument and received electronic medication monitors to use for similar to 3 months. Pharmacy records were queried regarding requested refills over the monitoring period; medication possession ratio (MPR) was calculated.Results: Of the 137 total participants, those who answered "Very confident" to the question, "How confident are you that you always remember to use your glaucoma medications?" and "No" to the question, "In the past 4 weeks, did you ever forget to take your medicine?" were more likely [odds ratio (OR) 2.78, 95% confidence interval (CI) 1.19-6.52] to take >= 80% of the prescribed doses according to electronic medication monitors. Mean MPR was 1.49, standard deviation (SD) 0.82, range 0.1-5.31. The proportion of participants taking greater than or equal to 80% of the prescribed doses according to the electronic monitors was 59% for participants with MPR 1.8 (n = 25).Conclusions: Asking about confidence may be a good method of screening for poor adherence for glaucoma medication. MPR may be an inadequate representation of glaucoma medication adherence.