Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrix
Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrix
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DOI：
10.1128/jvi.76.13.6857-6862.2002
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发表时间：
2002-07-01
影响因子：
5.4
通讯作者：
Göttlinger, HG
中科院分区：
文献类型：
--
作者：
Dorfman, T;Popova, E;Göttlinger, HG
Nef 增强人类免疫缺陷病毒 1 型基质 (MA) 蛋白的丝氨酸磷酸化，这表明 MA 可能是 Nef 的功能靶点。使用尽管缺乏大部分或全部MA但仍然具有感染性的突变体，我们在本研究中表明，即使MA完全被异源脂质锚取代，Nef增强病毒感染性的能力也不会受到损害。
Nef enhances the serine phosphorylation of the human immunodeficiency virus type 1 matrix (MA) protein, which suggests that MA may be a functional target of Nef. Using mutants that remain infectious despite the absence of most or all of MA, we show in the present study that the ability of Nef to enhance virus infectivity is not compromised even if MA is entirely replaced by a heterologous lipid anchor.