Comparison of clinical outcomes and characteristics between patients with and without hypertension in moyamoya disease
Comparison of clinical outcomes and characteristics between patients with and without hypertension in moyamoya disease
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烟雾病合并高血压患者和非高血压患者的临床结局和特征比较
DOI：
10.1016/j.jocn.2019.12.016
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发表时间：
2020-05-01
影响因子：
2
通讯作者：
Zhao, Jizong
中科院分区：
文献类型：
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作者：
Ma, Yonggang;Zhao, Meng;Zhao, Jizong
目的：本研究旨在比较高血压组和非高血压组烟雾病（MMD）患者的差异。方法：回顾性分析2009年至2016年我院收治的542例烟雾病成人患者。根据纳入标准，将烟雾病患者分为两组（高血压组和非高血压组），并总结其临床特征。此外，我们还探讨了高血压组不良结果的危险因素。结果：在 542 名成年烟雾病患者中，我们发现 156 名患者（28.8%）患有高血压，386 名患者（71.2%）没有高血压。随访中我们认为非高血压组的预后明显优于高血压组(P=0.005)，而高血压患者更容易发生并发症(P=0.037)。在多变量分析中，严重高血压（OR，2.746；95% CI，1.096-6.822；P = 0.031）和未服用抗高血压药物（OR，0.342；95% CI，0.131-1.895；P = 0.029）是术后不良结局的独立预测因素。烟雾病的常见手术方式（直接和间接搭桥）在预防成人MMD高血压患者未来不良结局方面没有显着差异。结论：我们建议，严重高血压和未服用抗高血压药物是成人MMD高血压患者不良临床结局的独立危险因素。 (C) 2019 年由爱思唯尔有限公司出版。
Objective: Our study aimed to compare the disparity of patients with moyamoya disease (MMD) between hypertension group and non-hypertension group. And we attempt to explore the risk factors for MMD with hypertension.Methods: We retrospectively analyze 542 adult patients with moyamoya disease admitted to our hospital from 2009 to 2016. In view of inclusion criteria, we divided patients with moyamoya disease into two groups (hypertension group and non-hypertension group) and summarized their clinical characteristics. Furthermore, we explore the risk factors for unfavorable outcomes in hypertension group.Results: Of 542 adult patients with moyamoya disease, we identified 156 patients (28.8%) with hypertension and 386 patients (71.2%) without hypertension. During follow-up, we hold the views that the prognosis of non-hypertension group was obviously better than hypertension group (P = 0.005) and the complications were prone to occurring to patients with hypertension (P = 0.037). In the multivariate analysis, severe hypertension (OR, 2.746; 95% CI, 1.096-6.822; P = 0.031) and no anti-hypertensive medication (OR, 0.342; 95% CI, 0.131-1.895; P = 0.029) were the independent predictors for postoperative unfavorable outcomes. The common surgical modalities of moyamoya disease (direct and indirect bypass) had no significant difference in future unfavorable outcomes prevention in adult MMD patients with hypertension.Conclusions: We suggested severe hypertension and no anti-hypertensive medication as the independent risk factors for unfavorable clinical outcomes in adult MMD with hypertension. (C) 2019 Published by Elsevier Ltd.