Effects of cadmium on preimplantation mouse embryos in vitro with special reference to their implantation capacity and subsequent development.
Effects of cadmium on preimplantation mouse embryos in vitro with special reference to their implantation capacity and subsequent development.
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镉对体外植入前小鼠胚胎的影响，特别是其植入能力和随后的发育。
DOI：
10.1002/tera.1420320304
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
S. Chan
中科院分区：
文献类型：
--
作者：
H. Yu;P. Tam;S. Chan
短时间暴露于5或10 μ g/ml氯化镉24小时，干扰F1（C57雌性X A2 G雄性）小鼠四细胞和桑椹期胚胎的体外发育。桑椹胚对镉的敏感性低于四细胞胚胎。然而，通过压缩桑椹胚的四细胞胚胎的体外发育没有受到影响，虽然大多数处理过的胚胎退化和解压缩后。有人提出，镉的毒性可能不是通过对细胞表面和细胞骨架的接触效应。它可能会干扰细胞的一般能量代谢。虽然1微克/毫升的镉并没有干扰随后的体外发育超过植入阶段，在体内植入的能力降低后，观察到手术转移到受体。尽管镉盐对母体的影响，目前的结果表明，不能排除镉的直接胚胎毒性和致畸活性。
A short exposure to 5 or 10 micrograms/ml cadmium chloride for 24 hours disturbed the in vitro development of four-cell and morula-stage embryos of F1 (C57 female X A2G male) mice. Morulae appeared to be less sensitive to cadmium than four-cell embryos. However, the in vitro development of four-cell embryos through compaction to morulae was not affected, though most treated embryos degenerated and decompacted later. It was proposed that cadmium toxicity may not be acting through contact effects on the cell surface and cytoskeleton. It probably interferes with the general energy metabolism of the cells. Although 1 microgram/ml cadmium did not disturb the subsequent in vitro development beyond the implantation stage, a reduced capacity of implantation in vivo was observed after surgical transfer to recipients. In spite of the effects of cadmium salts on the maternal side, the present results suggest that a direct embryotoxic and teratogenic activity of cadmium cannot be excluded.
吸烟孕妇的母血、胎儿脐带血和胎盘组织中的镉含量。
影响因子：
9.8
作者：
Kuhnert,PM;Kuhnert,BR;Bottoms,SF;Erhard,P
通讯作者：
Erhard,P