Modification of phallus development and sexual behavior in rats treated with gonadotropin antiserum neonatally.
Modification of phallus development and sexual behavior in rats treated with gonadotropin antiserum neonatally.
复制标题
新生儿用促性腺激素抗血清治疗的大鼠阴茎发育和性行为的改变。
作者：
Bruce D. Goldman;David M. Quadagno;J. Shryne;R. Gorski
Male rats were injected with gonadotropin antiserum (GTH A/S) or normal rabbit serum on days 1, 3, and 5 of life. The former animals had normal testis growth and spermatic development at maturity; however, they failed to impregnate normal females with which they cohabited. The reproductive failure of these rats may have been largely a result of an incomplete pattern of masculine sexual behavior. It was found that the experimental males achieved very few intromissions and ejaculations in sex behavior tests when compared to control males injected with normal rabbit serum. Since the phallus was underdeveloped in GTH A/S treated males, these data do not distinguish between a peripheral or central neural cause for the behavioral deficit. However, the same males showed high levels of feminine sexual behavior after estrogen-progesterone priming, suggesting that behavioral centers in the CNS had not been “masculinized” during neonatal life. Nevertheless, masculinization of the GTH release mechanism(s) apparently ...
