Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis
Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis
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DOI：
10.1111/j.1399-5618.2006.00296.x
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发表时间：
2006-04-01
影响因子：
5.4
通讯作者：
Soares, JC
中科院分区：
文献类型：
--
作者：
Glahn, DC;Bearden, CE;Soares, JC
背景：虽然双相情感障碍和精神分裂症长期以来被视为不同的疾病，但越来越多的证据表明，这两种复杂的疾病有一些共同的基因，可能表现为重叠的神经心理障碍。虽然工作记忆功能障碍已被认为是精神分裂症病理生理学的核心，但在双相情感障碍的研究中却很少受到关注。方法：我们对精神分裂症患者（n = 15）、分裂情感障碍患者（n = 15）、精神病性双相情感障碍患者（n = 11）和非精神病性双相情感障碍患者（n = 15）以及人口统计学上匹配的健康受试者（n = 32）进行了工作记忆测量，以确定这些群体表现出常见或独特障碍的程度。结果：双相情感障碍患者（有或没有精神病特征）和精神分裂症/分裂情感障碍患者在向后手指广度上存在障碍，而只有具有精神病特征的终生病史的患者，无论是否诊断，在空间延迟反应任务上存在障碍。结论：在双相情感障碍和精神分裂症中，向后手指广度表现具有可比性，并且可能是跨诊断类别的合适的内表型标记。相比之下，空间工作记忆表现明显区分非精神病性双相情感障碍患者和功能性精神病患者。
Background: Although bipolar disorder and schizophrenia have long been viewed as distinct illnesses, there is growing evidence that these two complex diseases share some common genes, which may manifest as overlapping neuropsychological impairments. Although working memory dysfunction has been proposed to be central to the pathophysiology of schizophrenia, it has received less attention in studies of bipolar disorder.Method: We applied measures of working memory to patients with schizophrenia (n = 15), patients with schizoaffective disorder (n = 15), patients with psychotic (n = 11) and non-psychotic (n = 15) bipolar disorder, and demographically matched healthy subjects (n = 32), in order to determine the extent to which these groups show common or unique impairments.Results: While patients with bipolar disorder (with and without psychotic features) and those with schizophrenia/schizoaffective disorder were impaired on backward digit span, only patients with a lifetime history of psychotic features, regardless of diagnosis, were impaired on spatial delayed response task.Conclusions: Backward digit span performance is comparable in bipolar disorder and schizophrenia, and may be an appropriate endophenotypic marker that cuts across diagnostic categories. In contrast, spatial working memory performance clearly distinguishes non-psychotic bipolar disorder patients from patients with functional psychosis.