Kaposi sarcoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy.
Kaposi sarcoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy.
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DOI：
10.1038/sj.bjc.6604520
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发表时间：
2008-09-02
影响因子：
8.8
通讯作者：
Clifford, G. M.
中科院分区：
文献类型：
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作者：
Franceschi, S.;Dal Maso, L.;Rickenbach, M.;Polesel, J.;Hirschel, B.;Cavassini, M.;Bordoni, A.;Elzi, L.;Ess, S.;Jundt, G.;Mueller, N.;Clifford, G. M.
1984年至2006年间，瑞士HIV队列研究中，12959名HIV/AIDS （PWHA）患者共进行了73412人年（py）的随访，其中35551名PWHA患者接受了高效抗逆转录病毒治疗（HAART）。发现597例卡波西肉瘤（KS），其中52例为HAART使用者。采用Cox回归估计风险比（HR）和相应的95%置信区间（CI）。卡波西肉瘤的发病率在1996-1998年间突然下降，之后达到每1000年1.4例的稳定水平。在非洲或中东出生的男男性行为者和非HAART使用者都与KS有关，但CD4细胞计数的风险模式不同。只有极低的CD4细胞计数（<50 μl−1）在入组或HAART开始时与HAART使用者的KS显著相关。在HAART开始治疗后的头几个月，KS的HR急剧下降，并在7-10年后继续保持较低（HR, 0.06; 95% CI, 0.02-0.17）。在HAART使用者中，52例KS病例中有33例（63.5%）发生在停止治疗或使用HAART不到6个月的PWHA患者中。
Between 1984 and 2006, 12 959 people with HIV/AIDS (PWHA) in the Swiss HIV Cohort Study contributed a total of 73 412 person-years (py) of follow-up, 35 551 of which derived from PWHA treated with highly active antiretroviral therapy (HAART). Five hundred and ninety-seven incident Kaposi sarcoma (KS) cases were identified of whom 52 were among HAART users. Cox regression was used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (CI). Kaposi sarcoma incidence fell abruptly in 1996–1998 to reach a plateau at 1.4 per 1000 py afterwards. Men having sex with men and birth in Africa or the Middle East were associated with KS in both non-users and users of HAART but the risk pattern by CD4 cell count differed. Only very low CD4 cell count (<50 cells μl−1) at enrolment or at HAART initiation were significantly associated with KS among HAART users. The HR for KS declined steeply in the first months after HAART initiation and continued to be low 7–10 years afterwards (HR, 0.06; 95% CI, 0.02–0.17). Thirty-three out of 52 (63.5%) KS cases among HAART users arose among PWHA who had stopped treatment or used HAART for less than 6 months.
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影响因子：
6.2
作者：
Mocroft, A;Kirk, O;Lundgren, JD
通讯作者：
Lundgren, JD
影响因子：
3.8
作者：
Silverberg, Michael J.;Neuhaus, Jacqueline;Abrams, Donald I.
通讯作者：
Abrams, Donald I.
影响因子：
10.3
作者：
Appleby, P;Beral, V;Carpenter, L
通讯作者：
Carpenter, L
影响因子：
--
作者：
Ledergerber, B;Telenti, A;Egger, M
通讯作者：
Egger, M
DOI：
10.1093/jnci/djm010
发表时间：
2007-06-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Biggar, Robert J.;Chaturvedi, Anil K.;Engels, Eric A.
通讯作者：
Engels, Eric A.