Misonidazole enhancement of acute and late radiation injury to the rat spinal cord.
Misonidazole enhancement of acute and late radiation injury to the rat spinal cord.
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DOI：
10.1038/bjc.1979.153
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发表时间：
1979-07
影响因子：
8.8
通讯作者：
Yuhas, J M
中科院分区：
文献类型：
--
作者：
Yuhas, J M
*所有死亡都发生在接触后24小时内；目前正在跟踪幸存者进行晚期瘫痪分析。T1400-3000rad脊髓；暴露细节如图所示。仅相对于X射线的IP‘<；0-001；仅相对于药物的P<；0-025。？仅与X射线有关的P<；005，(仅限irtig，在X射线之后。如表所示，没有造成急性死亡，注射后45分钟，给予如上所述的分级剂量的局部X射线。这张图总结了暴露后9-5个月的这项初步研究的结果，并显示了MIS使大鼠对辐射诱导的脊髓瘫痪敏感。在50%的受照大鼠(Finney，1962)中，引起瘫痪所需的放射剂量在对照组为2246 rad，在注射MI的大鼠为1744 rad。根据是否包括或排除高剂量对照组和在显着性检验中所做的假设，1P28(2246/1744)的增敏比在5%0概率水平上刚刚达到或刚刚错过统计学意义。由于这些数据是初步的，而且可以很容易地从数字中收集到raxv数据，所以我们留下了统计意义的问题。图中还包括在相同条件下给予辐射防护剂WR-2721(200 mg/kg，暴露前15分钟)的大鼠的数据。从其他对这一能力的分析中可以预测
* All deaths occuirred within 24 h after exposure; survivors are at present being followed for analysis of late paralysis. t 1400-3000 rad to the spinal cord; details of exposure as in Figure. Ip'< 0-001 relative to X-rays only; P< 0-025 relative to drug only. § P< 0 05 relative to X-rays only,(irtig only, an (d (I1tg after X-rays. which, as shown in the Table, produces no acute deaths, and 45 min after injection the rats were given graded doses of local-ized X-rays as above. The Figure summarizes the results of this pilot study through 9-5 months from exposure, and shows that MIS sensitized the ratsto radiation-induced spinal-cord paralysis. Theradiation doses required to p) roduce paralysis in 50%'of the irradiated rats (Finney, 1962) were 2246 rad in control rats and 1744 rad in MIS-injected rats. Depending on whether one includes or excludes the high-dose control groups and the assumptions made in significance testing, this sensitizer enhancement ratio of 1P28 (2246/1744) just achieves or just misses statistical significance at the 5% 0 probability level. Since these data are preliminary, and the raxv datacan be gleaned readily from the Figure, we leave the question of statistical significanceopen. Also included in the Figure are data for rats given the radioprotectant WR-2721 (200 mg/kg, 15 min before exposure) under the same conditions. As would be predicted from other analyses on the ability of this