Extent of silent cerebral infarcts in adult sickle-cell disease patients on magnetic resonance imaging: is there a correlation with the clinical severity of disease?
Extent of silent cerebral infarcts in adult sickle-cell disease patients on magnetic resonance imaging: is there a correlation with the clinical severity of disease?
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DOI：
10.4081/hr.2013.e3
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发表时间：
2013-01-25
影响因子：
0.9
通讯作者：
Petsas T
中科院分区：
文献类型：
--
作者：
Solomou E;Kraniotis P;Kourakli A;Petsas T
本文的目的是将磁共振成像 (MRI) 上的无症状脑梗塞 (SCI) 程度与成年患者镰状细胞病 (SCD) 的临床严重程度相关联。连续 24 名平均年龄为 38.4 岁（范围 20-59 岁）的成年无症状 SCD 患者（11 名男性和 13 名女性）在带有专用头部线圈的 1 Tesla Gyroscan Intera、Philips MR 扫描仪上接受脑部 MRI 检查。该协议包括轴向和冠状平面上的 TSE T2 加权图像和 FLAIR 图像。 MRI 读数由两名放射科医生进行并达成一致读数。患者是复合杂合子（HbS/β-thal）。 SCI 的程度分为 0-2 级，0 表示无损伤。血液学家根据血管闭塞危象的频率和严重程度将临床严重程度分为 0-2 级。临床疾病的严重程度与 MR 成像上的 SCI 范围之间没有统计学上显着的相关性。年轻和老年患者的 SCI 病变范围没有统计学差异。接受羟基脲治疗的患者 SCI 病变程度没有统计学上的显着差异。杂合子 (HbS/β-thal) SCD 患者的 SCI 程度与年龄无关，即使在年轻（<38.4 岁）患者中也可能相当严重。然而 SCI 的程度与临床疾病的严重程度并不相关。
The aim of this paper is to correlate the extent of silent cerebral infarcts (SCIs) on magnetic resonance imaging (MRI) with the clinical severity of sickle cell disease (SCD) in adult patients. Twenty-four consecutive adult asymptomatic SCD patients (11 male and 13 female) with a mean age of 38.4 years (range 20-59) were submitted to brain MRI on a 1 Tesla Gyroscan Intera, Philips MR scanner with a dedicated head coil. The protocol consisted of TSE T2-weighted and FLAIR images on the axial and coronal planes. MRI readings were undertaken by two radiologists and consensus readings. Patients were compound heterozygotes (HbS/β-thal). The extent of SCIs was classified from 0-2 with 0 designating no lesions. Clinical severity was graded as 0-2 by the hematologist, according to the frequency and severity of vaso-occlusive crises. There was no statistically significant correlation between the severity of clinical disease and the extent of SCIs on MR imaging. The extent of SCI lesions did not differ statistically between younger and older patients. Patients receiving hydroxyurea had no statistically significant difference in the extent of SCI lesions. The extent of SCIs in heterozygous (HbS/β-thal) SCD patients is not age related and may be quite severe even in younger (<38.4 years) patients. However the extent of SCIs is not correlated with the severity of clinical disease.