Platelet hyperreactivity: Predictive and intrinsic properties
Platelet hyperreactivity: Predictive and intrinsic properties
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DOI：
10.1016/j.hoc.2007.06.002
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发表时间：
2007-08-01
影响因子：
2.4
通讯作者：
Bray, Paul F.
中科院分区：
文献类型：
--
作者：
Bray, Paul F.
血小板血栓是大多数血管缺血事件发生的中心环节。血小板反应性存在明显的个体差异，一些受试者显示血小板高反应性。越来越多的报告表明，有血小板功能的实验室测量，预测临床血栓形成事件。血小板功能的一些但不是全部测量是可重现的。血小板高反应性可通过多种试验中的多种刺激进行评估，更可能存在于女性和纤维蛋白原水平升高的受试者中。
Platelet thrombi are central to the development of most vascular ischemic events. There is marked interindividual variation in platelet responsiveness, with some subjects displaying platelet hyperreactivity. An increasing number of reports indicate that there are laboratory measures of platelet function that predict clinical thrombotic events. Some, but not all, measures of platelet function are reproducible. Platelet hyperreactivity can be assessed with multiple stimuli in multiple assays and is more likely to be present in women and in subjects who have elevated fibrinogen levels.