A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload.
A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload.
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DOI：
10.1016/j.bpj.2011.11.1931
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发表时间：
2012
影响因子：
2.4
通讯作者：
Roy C. P. Kerckhoffs;J. Omens;A. McCulloch
中科院分区：
文献类型：
--
作者：
Roy C. P. Kerckhoffs;J. Omens;A. McCulloch
结论：心肌细胞肥大和肌纤维密度降低是HCM中Fmax降低的基础，并伴有厚肌蛋白和薄肌蛋白突变。
Conclusion: Cardiomyocyte hypertrophy and reduced myofibrillar density underlie depressed Fmax in HCM with mutations in thick and thin sarcomeric proteins.