Do myoepithelial cells hold the key for breast tumor progression?
Do myoepithelial cells hold the key for breast tumor progression?
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DOI：
10.1007/s10911-005-9584-6
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Hu, M
中科院分区：
文献类型：
--
作者：
Polyak, K;Hu, M
乳腺肌上皮细胞一直是乳腺癌生物学的一个被忽视的方面，很大程度上被忽视，因为它们被认为是不太重要的肿瘤发生比管腔上皮细胞，大多数乳腺癌被认为是从产生。近年来，随着我们对干细胞生物学和细胞微环境的了解不断增加，肌上皮细胞慢慢开始获得更多的关注。新出现的数据提出了这样一个假设，即肌上皮细胞是否通过调节原位癌向浸润性癌的转变在乳腺肿瘤进展中起关键作用，以及肌上皮细胞是否是乳腺干细胞小生境的一部分。已知肌上皮细胞和腔上皮细胞之间的旁分泌相互作用对于调节细胞周期进程、建立上皮细胞极性以及抑制细胞迁移和侵袭是重要的。基于这些功能，正常乳腺肌上皮细胞被称为“天然肿瘤抑制因子”。然而，在肿瘤进展过程中，肌上皮细胞似乎失去了这些特性，最终随着肿瘤的侵袭性，这种细胞群会减少。更好地了解肌上皮细胞的功能及其在肿瘤进展中的作用可能会导致其用于癌症治疗和预防措施。
Mammary myoepithelial cells have been a neglected facet of breast cancer biology, largely ignored since they have been considered to be less important for tumorigenesis than luminal epithelial cells from which most of breast carcinomas are thought to arise. In recent years as our knowledge of stem cell biology and the cellular microenvironment has been increasing, myoepithelial cells are slowly starting to gain more attention. Emerging data raise the hypothesis whether myoepithelial cells play a key role in breast tumor progression by regulating the in situ to invasive carcinoma transition and that myoepithelial cells are part of the mammary stem cell niche. Paracrine interactions between myoepithelial and luminal epithelial cells are known to be important for regulation of cell cycle progression, establishing epithelial cell polarity, and inhibiting cell migration and invasion. Based on these functions, normal mammary myoepithelial cells have been called "natural tumor suppressors." However, during tumor progression myoepithelial cells seem to loose these properties, and eventually this cell population diminishes as tumors become invasive. Better understanding of myoepithelial cell function and their role in tumor progression may lead to their exploitation for cancer therapeutic and preventative measures.