MYELINATION OF RAT SCIATIC NERVE: COMPARISON OF UNDERNUTRITION AND CHOLESTEROL BIOSYNTHESIS INHIBITION
MYELINATION OF RAT SCIATIC NERVE: COMPARISON OF UNDERNUTRITION AND CHOLESTEROL BIOSYNTHESIS INHIBITION
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大鼠坐骨神经髓鞘形成：营养不良与胆固醇生物合成抑制的比较
DOI：
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发表时间：
1973
影响因子：
3.2
通讯作者：
E. Hedley‐Whyte
中科院分区：
文献类型：
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作者：
E. Hedley‐Whyte
本文研究了部分喂养和随后自由喂养对大鼠坐骨神经髓鞘形成的影响，并与每日腹腔注射胆固醇生物合成抑制剂AY 9944（反式-1，4-双-（2-氯苄基氨基甲基）环己烷二盐酸盐）的影响进行了比较。比较了实验组和对照组同窝仔坐骨神经电镜下髓鞘厚度的频率分布以及轴突周长与髓鞘厚度的关系。营养不良和给予一种降血糖药物（AY 9944）对髓鞘形成大鼠坐骨神经有不同的影响。在4 ~ 12、4 ~ 18和12 ~ 26日龄，营养不良对大鼠坐骨神经髓鞘形成的影响大于轴突的周向生长。4-12日龄营养不良引起的髓鞘形成延迟在26日龄时仍然明显，但在34日龄时不明显，而4 - 18日龄营养不良后的髓鞘形成延迟在46日龄时仍然存在。AY 9944对髓鞘厚度的频率分布没有影响，尽管从2日龄开始每天注射的11日龄大鼠中有22%的许旺细胞含有结晶和层状内含物;并且AY 9944处理的大鼠体重增加速度低于其同窝出生的大鼠。在大鼠周围神经发育的关键时期，营养不良会导致髓鞘积累不足，而这并不能完全解释为全身性生长迟缓。
The effects of partial feeding and subsequent free feeding on myelination of rat sciatic nerve were investigated and compared with the effects of daily i.p. administration of AY9944 (trans-1, 4-bis-(2-chlorobenzylaminomethyl)-cyclohexane dihydrochloride), a cholesterol biosynthesis inhibitor. The frequency distributions of myelin sheath thicknesses in electron micrographs of sciatic nerves of experimental and control littermates were compared together with the relationships of axon circumference to myelin sheath thickness. Undernutrition and administration of a hypocholesteremic drug (AY9944) had dissimilar effects on myelinating rat sciatic nerve. Myelination of rat sciatic nerve was retarded more than the circumferential growth of the axon by undernutrition from 4 to 12, 4 to 18, and 12 to 26 days of age. The retardation of myelination caused by undernutrition from 4–12 days of age was still evident at 26 days of age but not at 34 days of age, whereas retardation of myelination after undernutrition from 4 to 18 days of age was still present at 46 days of age. AY9944 had no effect on the frequency distributions of myelin sheath thickness although 22% of Schwann cells in the 11 day old rats injected daily from 2 days of age contained crystalline and lamellar inclusions; and the AY9944 treated rats gained weight less quickly than their littermates. Undernutrition during a critical period in the development of rat peripheral nerve can cause deficits in myelin accumulation not fully accounted for by generalized growth retardation.