RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer.
RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer.
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DOI：
10.2174/1568009616666151112122801
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发表时间：
2016-01
影响因子：
3
通讯作者：
C. Uchida;M. Kitagawa
中科院分区：
文献类型：
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作者：
C. Uchida;M. Kitagawa
在泛素化系统中，E3泛素连接酶在决定底物特异性和催化泛素从E2酶转移到底物中起关键作用。越来越多的证据表明，E3泛素连接酶参与癌症的发生和发展。RING型和HECT型E3连接酶是E3泛素连接酶的经典分类组，并且这些酶中的更多被显示为癌症治疗的潜在靶标。最近分类的RBR E3连接酶通过RING/HECT杂交样机制催化泛素的转移。值得注意的是，这些连接酶也被强调为癌症治疗药物靶点的重要潜在候选者。本文综述了RING型、HECT型和RBR型E3连接酶，并讨论了它们在癌症和癌症治疗中的作用。
In the ubiquitylation system, E3 ubiquitin ligases play a key role in determining substrate specificity and catalyzing the transfer of ubiquitin from E2 enzymes to the substrate. Growing evidence has shown that E3 ubiquitin ligases are involved in cancer development and progression. The RING-type and HECT-type E3 ligases are the classically categorized groups of E3 ubiquitin ligases, and more of these enzymes are being shown to be potential targets for cancer therapy. The recently classified RBR E3 ligases catalyze the transfer of ubiquitin by a RING/HECT hybrid-like mechanism. Notably, these ligases are also emphasized as important potential candidates for targets of cancer treatment drugs. The present review provides an overview of the RING-, HECT- and RBR-type E3 ligases, and discusses their roles in cancer and cancer therapy.