Inhibitory Effects of Tea Catechins, Black Tea Extract and Oolong Tea Extract on Hepatocarcinogenesis in Rat
Inhibitory Effects of Tea Catechins, Black Tea Extract and Oolong Tea Extract on Hepatocarcinogenesis in Rat
复制标题
茶儿茶素、红茶提取物和乌龙茶提取物对大鼠肝癌的抑制作用
DOI：
10.1111/j.1349-7006.1996.tb03106.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Y. Hara
中科院分区：
文献类型：
--
作者：
N. Matsumoto;T. Kohri;K. Okushio;Y. Hara
研究了各种茶儿茶素（(‐)‐表儿茶素、(‐)‐表没食子儿茶素、(‐)‐表儿茶素没食子酸酯、(‐)‐表没食子儿茶素没食子酸酯）、红茶提取物和乌龙茶提取物对肝癌发生的抑制作用。雄性 F344 大鼠接受单剂量二乙基亚硝胺（200 mg/kg，腹腔注射），然后在饮用水中施用苯巴比妥（0.05%），持续 6 周。在整个实验期间、仅在起始期或仅在推广期给予茶儿茶素、红茶提取物或乌龙茶提取物。所有四种茶儿茶素、红茶提取物和乌龙茶提取物（0.05 或 0.1%）均显着减少肝脏中癌前谷胱甘肽 S-转移酶胎盘形式阳性病灶的数量和面积。这些结果表明，茶儿茶素、红茶提取物和乌龙茶提取物对肝癌发生具有化学预防作用。
Inhibitory effects of individual tea catechins ((‐)‐epicatechin, (‐)‐epigallocatechm, (‐)‐epicatechin gallate, (‐)‐epigallocatechin gallate), black tea extract and oolong tea extract on hepatocarcinogenesis were investigated. Male F344 rats received a single dose of diethylnitrosamine (200 mg/kg, i.p.), and thereafter phenobarbital (0.05%) was administered in the drinking water for a period of 6 weeks. Tea catechins, black tea extract or oolong tea extract were given during the entire experimental period, during only the initiation period or during only the promotion period. All four tea catechins, black tea extract and oolong tea extract (0.05 or 0.1%) significantly decreased the number and area of preneoplastic glutathione S‐transferase placental form‐positive foci in the liver. These results suggest that tea catechins, black tea extract and oolong tea extract have a chemopreventive action against hepatocarcinogenesis.
绿茶和红茶对 A/J 小鼠 4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁酮生物活化、DNA 甲基化和肺肿瘤发生的影响。
影响因子：
11.2
作者：
Shi,ST;Wang,ZY;Smith,TJ;Hong,JY;Chen,WF;Ho,CT;Yang,CS
通讯作者：
Yang,CS