Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort - Associations with gender and glycemia
Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort - Associations with gender and glycemia
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DOI：
10.2337/diacare.26.3.810
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发表时间：
2003-03-01
期刊：
影响因子：
16.2
通讯作者：
Klein, RL
中科院分区：
文献类型：
--
作者：
Jenkins, AJ;Lyons, T;Klein, RL
1997-1999年糖尿病控制和并发症试验/糖尿病干预和并发症的流行病学研究设计和方法（DCCT/EDIC）队列中，来自428名女性和540名男性的血清通过常规脂质、NMR、载脂蛋白水平和LDL对体外氧化的敏感性来表征。计算每个脂蛋白相关参数与性别的简单相关系数和偏相关系数，包括和不包括协变量（年龄、糖尿病病程、并发HbA 1c、DCCT随机化、高血压、BMI、腰臀比和白蛋白尿）。对于并发HbA（1c），数据分析如上，HbA（1c）交换性别。如果P
Objective-To relate the nuclear magnetic resonance (NMR)-determined lipoprotein profile, conventional lipid and apolipoprotein measures, and in vitro oxidizibility of LDL with gender and glycemia in type 1 diabetes.Research Design and Methods-in the 1997-1999 Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC) cohort, serum from 428 women and 540 men were characterized by conventional lipids, NMR, apolipoprotein levels, and LDL susceptibility to in vitro oxidation. Simple and partial correlation coefficients were calculated for each lipoprotein-related parameter versus gender, with and without covariates (age, diabetes duration, concurrent HbA(1c), DCCT randomization, hypertension, BMI, waist-to-hip ratio, and albuminuria). For concurrent HbA(1c), data were analyzed as above, exchanging gender for HbA(1c). Associations were significant if P