Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants
Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants
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DOI：
10.1128/iai.66.5.2093-2098.1998
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发表时间：
1998-05-01
影响因子：
3.1
通讯作者：
Leroy, O
中科院分区：
文献类型：
--
作者：
Dagan, R;Eskola, J;Leroy, O
过多的新发现的疫苗意味着，在未来，许多疫苗将不得不同时给予婴儿。我们检测了几种含有相同蛋白质成分的疫苗（即破伤风圆环（TT））对免疫应答的潜在干扰，婴儿同时接种与TT （PncT）结合的四价肺炎球菌疫苗和白喉-破伤风-百日咳-脊髓灰质炎病毒-乙型流感嗜血杆菌-破伤风结合疫苗，其抗h抗体明显降低。b型流感多糖（磷酸多核糖苷糖醇[PRP]）抗体浓度高于接受白喉类四价肺炎球菌结合疫苗或安慰剂的人。一项剂量范围研究表明，抗prp抗体浓度与婴儿期接种的PncT疫苗的TT含量呈负相关。接种疫苗后抗破伤风抗体浓度也会随着TT含量的增加而受到不利影响。我们认为，这种现象是由共同蛋白载体的干扰引起的，在考虑引入包括多种结合疫苗在内的免疫计划时，应考虑到这一点。
The plethora of newly discovered vaccines implies that, in the future, many vaccines will have to be administered simultaneously to infants. We examined the potential interference with the immune response of several coadministered vaccines containing the same protein component, namely, tetanus toroid (TT), Infants simultaneously receiving a tetravalent pneumococcal vaccine conjugated to TT (PncT) and a diphtheria-tetanus-pertussis-poliovirus-Haemophilus influenzae type b-tetanus conjugate vaccine showed significantly lower anti-H. influenzae type b polysaccharide (polyribosylribitol phosphate [PRP]) antibody concentrations than those receiving either a tetravalent pneumococcal vaccine conjugated to diphtheria toroid or placebo. A dose range study showed that anti-PRP antibody concentrations were inversely related to the TT content of the PncT vaccines administered in infancy. Postimmunization antitetanus antibody concentrations were also affected adversely as the TT content of the coadministered vaccines was increased, This phenomenon, which we believe derives from interference by a common protein carrier, should be taken into account when the introduction of an immunization program including multiple conjugate vaccines is considered.