Characterization of zymosan-induced arthritis in the rat: Effects on joint inflammation and cartilage metabolism
Characterization of zymosan-induced arthritis in the rat: Effects on joint inflammation and cartilage metabolism
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DOI：
10.1016/0024-3205(94)00771-3
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发表时间：
1994-01-01
期刊：
影响因子：
6.1
通讯作者：
Netter, P.
中科院分区：
文献类型：
--
作者：
Gegout, P.;Gillet, P.;Netter, P.
D0单次关节内注射2 mg酵母多糖可导致急性关节周围水肿和亚急性侵蚀性滑膜炎。酵母多糖诱导的关节炎的发展与最初的跑步活动丧失和最初的蛋白多糖合成减少有关。仅在d1出现发热反应。此外，在D20，滑膜血管疙瘩导致关节软骨中蛋白多糖含量的显著减少。当注射iA时，IL1-β(1mU·g)引起类似的发热和软骨合成代谢的类似变化，但不影响软骨蛋白多糖含量(D20)。这些结果表明，酵母多糖诱导的大鼠滑膜炎将早期前列腺素依赖过程(浮肿、疼痛、发热)与IL1对软骨代谢的影响结合在一起，从而使软骨保护药物的评估成为可能。
A single intra-articular (ia) injection of 2 mg zymosan on D0 led to the production of acute periarticular edema followed by subacute erosive synovitis. The development of the zymosan-induced arthritis was associated with an initial loss of running activity and with an initial decrease of proteoglycan synthesis. Febrile response was present only on D1. In addition, on D20 synovial pannus led to a marked depletion of the proteoglycan content in the articular cartilage. When injected ia, IL1-beta (1 mu-g) provoked similar fever and similar changes in cartilage anabolism, but did not affect cartilage proteoglycan content (D20). These results suggest that zymosan-induced synovitis in the rat combines early prostaglandin-dependent processes (edema, pain, fever) with IL1-related effects on cartilage metabolism, thus allowing evaluation of chondroprotective drugs.