Single-dose kinetics predict steady-state concentrations on imipramine and desipramine.
Single-dose kinetics predict steady-state concentrations on imipramine and desipramine.
复制标题
单剂量动力学预测丙咪嗪和地昔帕明的稳态浓度。
DOI：
10.1001/archpsyc.1980.01780160084010
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发表时间：
1980
影响因子：
--
通讯作者：
F. Goodwin
中科院分区：
文献类型：
--
作者：
W. Potter;A. Zavadil;I. Kopin;F. Goodwin
在治疗开始时单剂量预测三环类抗抑郁药的最终稳态浓度可能是一种有价值的治疗工具，但应用有限。我们证明了准确的稳态预测后，叔胺，盐酸丙咪嗪，和仲胺，盐酸地昔帕明，在一个仔细监测的长期治疗患者人群。结果表明，长期治疗不会改变丙咪嗪或地昔帕明的代谢。比较了使用总曲线下面积和24小时浓度进行单次给药预测的相对优点。这些发现表明，单剂量预测可用作实用的治疗和研究工具。
Single-dose prediction of ultimate steady-state concentrations of tricyclic antidepressants at the outset of treatment can be a valuable therapeutic tool that has had only limited application. We demonstrate accurate steady-state predictions following both the tertiary amine, imipramine hydrochloride, and the secondary amine, desipramine hydrochloride, in a carefully monitored long-term treatment patient population. Results show that long-term treatment does not alter metabolism of either imipramine or desipramine. The relative merits of single-dose predictions using total and "abbreviated" areas under the curve and concentration at 24 hours are compared. These findings demonstrate that single-dose prediction can be used as a practical therapeutic, as well as, research tool.