CD33⁺/p-STAT1⁺ double-positive cell as a prognostic factor for stage IIIa gastric cancer.
CD33⁺/p-STAT1⁺ double-positive cell as a prognostic factor for stage IIIa gastric cancer.
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DOI：
10.1007/s12032-012-0442-2
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Zhang XS
中科院分区：
文献类型：
--
作者：
Dong J;Li J;Liu SM;Feng XY;Chen S;Chen YB;Zhang XS
尽管负责局部免疫逃逸的免疫细胞类型仍不清楚，但肿瘤浸润免疫细胞与肿瘤预后相关。本研究探讨了胃癌存活率与免疫细胞密度之间的关系，包括CD8+ T细胞、CD20+ B细胞和CD33+/p-STAT1+细胞（代表骨髓源性抑制细胞），以评估免疫细胞在胃癌进展中的作用。 2003年至2006年间，在中国中山大学肿瘤医院获得了100例经病理证实的IIIa期胃癌标本。使用免疫组织化学分析检查肿瘤组织中肿瘤浸润免疫细胞的密度。分析临床病理参数和存活率与免疫细胞密度的关系。高密度的 CD8+ T 细胞和 CD20+ B 细胞与良好的临床结果相关，但高密度的 CD33+/p-STAT1+ 细胞与不良的临床结果相关。最重要的是，CD33+/p-STAT1+细胞的密度是一个独立的预后因素，并且与CD8+T细胞的浸润呈负相关。尽管CD8+ T细胞和CD20+ B细胞的浸润参与了胃癌的进展，但这些数据表明CD33+/p-STAT1+细胞在局部免疫反应的调节中发挥核心作用，表明CD33+/p-STAT1+细胞可能是胃癌的治疗靶点。
Tumor-infiltrating immune cells are associated with tumor prognosis, although the type of immune cells responsible for local immune escape is still unknown. This study examined the relationship between gastric cancer survival and the density of immune cells, including CD8+ T cells, CD20+ B cells, and CD33+/p-STAT1+ cells, which represent myeloid-derived suppressor cells, to evaluate the role of immune cells in the progression of gastric cancer. One hundred pathologically confirmed specimens were obtained from stage IIIa gastric cancers between 2003 and 2006 at Sun Yat-sen University Cancer Center, China. The density of tumor-infiltrating immune cells in tumor tissue was examined using immunohistochemical analysis. Clinicopathologic parameters and the survival rate were analyzed in relation to the density of immune cells. A high density of CD8+ T cells and CD20+ B cells was associated with a good clinical outcome, but a high density of CD33+/p-STAT1+ cells was associated with a poor clinical outcome. Most importantly, the density of CD33+/p-STAT1+ cells was an independent prognostic factor and inversely related to the infiltration of CD8+ T cells. Although the infiltration of CD8+ T cells and CD20+ B cells is involved in the progression of gastric cancer, these data suggest that CD33+/p-STAT1+ cells play a central role in the regulation of the local immune response, suggesting that CD33+/p-STAT1+ cells might be therapeutic targets in gastric cancer.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
11.2
作者：
Halama, Niels;Michel, Sara;Jaeger, Dirk
通讯作者：
Jaeger, Dirk
影响因子：
158.5
作者：
Kantoff, Philip W.;Higano, Celestia S.;Young, J.
通讯作者：
Young, J.
影响因子：
11.2
作者：
Gobert, Michael;Treilleux, Isabelle;Menetrier-Caux, Christine
通讯作者：
Menetrier-Caux, Christine
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM