Borders, Extent, and Topography of Human Perirhinal Cortex as Revealed Using Multiple Modern Neuroanatomical and Pathological Markers
Borders, Extent, and Topography of Human Perirhinal Cortex as Revealed Using Multiple Modern Neuroanatomical and Pathological Markers
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DOI：
10.1002/hbm.20940
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发表时间：
2010-09-01
影响因子：
4.8
通讯作者：
Van Hoesen, Gary W.
中科院分区：
文献类型：
--
作者：
Ding, Song-Lin;Van Hoesen, Gary W.
尽管人们对人类内侧颞叶（MTL）不同组成部分在正常衰老和许多异常情况（如阿尔茨海默病和匹克病）中记忆和记忆障碍的具体贡献的兴趣迅速增加，但关于人类外周区35和36的边界、范围和地形的现代神经解剖学研究很少，这些区域是MTL记忆系统的重要组成部分。病理标记，主要包括神经元核抗原、钙结合蛋白（parvalbumin和calbinin - d28k）、非磷酸化神经丝蛋白（SMI-32）、紫菀凝集素、异常磷酸化tau蛋白（AT8），本研究发现人鼻周区35和36的边界与常规尼氏染色所定义的边界有显著差异。一般来说，35区和36区占据了腹内侧颞极区和鼻沟区、侧沟区以及梭状回或枕颞回的前三分之二。此外，根据鼻沟和侧沟的变化和其他有用的标志，在MTL的不同前后水平标记了人类35区和36区及其毗邻的嗅内皮层的精确边界、范围和地形。这些发现将为大量且迅速增加的人类MTI、健康和许多异常情况下的结构的神经影像学研究提供可靠的神经解剖学基础[j] .脑卒中杂志31 (3):1359-1379,2010 (C) 2010乳清-使用。公司
Despite rapidly increasing Interests in specific contributions of different components of human medial temporal lobe (MTL) to memory and memory impairments in normal aging and in many abnormal conditions such as Alzheimei's disease and Pick's disease, few modern neuroanatomical studies are available about the borders, extent, and topography of human perirhinal areas 35 and 36, which are important components of the MTL, memory system By a combined use of several cellular, neurochemical, and pathological markers, which mainly include neuronal nuclear antigen, calcium-binding proteins (parvalbumin and calbindin-D28k), nonphosphorylated neurofilament protein (SMI-32), Wisteria floribunda agglutinin, and abnormally phosphorylated tau (AT8), this study has revealed that the borders of human perirhinal areas 35 and 36 are significantly different from those defined with conventional Nissl staining. In general, areas 35 and 36 occupy the ventromedial temporopolar and rhinal sulcal regions, the collateral sulcal region, and the anterior two-thirds of fusiform gyrus or occipitotemporal gyrus Furthermore, the precise borders, extent, and topography of human areas 35 and 36 and adjoining entorhinal cortex were marked at different anteroposterior levels of the MTL with reference to variations of rhinal and collateral sulci and other useful landmarks. These findings would provide reliable neuroanatomical base for the great and yet rapidly increasing number of neuroimaging studies of the human MTI, structures in healthy and many abnormal conditions Hum Brain Mapp 31 1359-1379, 2010 (C) 2010 Whey-Use. Inc