Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study.
Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study.
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DOI：
10.1093/gerona/62.5.563
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发表时间：
2007-05
期刊：
影响因子：
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通讯作者：
N. Vogelzangs;A. Beekman;S. Kritchevsky;A. Newman;M. Pahor;K. Yaffe;S. Rubin;T. Harris;S. Satterfield;E. Simonsick;B. Penninx
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文献类型：
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作者：
N. Vogelzangs;A. Beekman;S. Kritchevsky;A. Newman;M. Pahor;K. Yaffe;S. Rubin;T. Harris;S. Satterfield;E. Simonsick;B. Penninx
社会心理因素与代谢异常有关，代谢异常增加心血管疾病和糖尿病的风险。本研究调查了以社区为基础的老年人样本中社会心理危险因素与代谢综合征之间的横断面关系。参与者是2917名年龄在70 - 79岁之间的人，他们参加了健康，衰老和身体成分研究。评估抑郁和焦虑症状、负性生活事件和情感支持不足，并计算汇总心理社会风险指数。代谢综合征定义为以下三个或更多标准：腹部肥胖、高甘油三酯、低高密度脂蛋白（HDL）胆固醇、高空腹血糖和高血压。结果在调整人口统计学和生活方式变量后，负性生活事件和情感支持不足增加了患代谢综合征的几率（每个生活事件的比值比[OR]= 1.13，95%置信区间[CI]= 1.05 - 1.22; OR = 1.35，95% CI = 1.10 - 1.66）。抑郁症状与代谢综合征之间的关系仅在白色人中发现（OR/SD = 1.11，95%CI = 1.01 - 1.23），而在黑人中未发现（OR/SD = 0.97，95%CI = 0.86 - 1.11）。男性焦虑症状与代谢综合征显著相关（OR = 1.13，95%CI = 1.00 - 1.28），而女性焦虑症状与代谢综合征无关（OR = 0.98，95%CI = 0.89 - 1.08）。此外，心理社会风险指数得分越高，患代谢综合征的概率越高（OR = 1.30，95%CI = 1.12 - 1.52）。结论：在老年人群中，不同的心理社会危险因素与代谢综合征的高患病率相关。减少或更好地管理心理社会风险因素是否可以改善代谢状况仍有待证明。
BACKGROUND Psychosocial factors have been associated with metabolic abnormalities that increase the risk of cardiovascular disease and diabetes. This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons. METHODS Participants were 2917 persons aged 70-79 years enrolled in the Health, Aging and Body Composition study. Depressive and anxiety symptoms, negative life events, and inadequate emotional support were assessed, and a summary psychosocial risk index was calculated. Metabolic syndrome was defined as three or more of the following criteria: abdominal obesity, high triglycerides, low high-density lipoprotein (HDL) cholesterol, high fasting glucose, and high blood pressure. RESULTS Negative life events and inadequate emotional support increased the odds of having metabolic syndrome after adjustment for demographic and lifestyle variables (odds ratio [OR] per life event = 1.13, 95% confidence interval [CI] = 1.05-1.22; OR = 1.35, 95% CI = 1.10-1.66, respectively). The relationship between depressive symptoms and metabolic syndrome was only found in white (OR per standard deviation [SD] = 1.11, 95% CI = 1.01-1.23), but not in black (OR per SD = 0.97, 95% CI = 0.86-1.11) persons. Anxiety symptoms were significantly associated with metabolic syndrome in men (OR per SD = 1.13, 95% CI = 1.00-1.28), but not in women (OR per SD = 0.98, 95% CI = 0.89-1.08). Moreover, a higher score on the psychosocial risk index was associated with an increased probability of having the metabolic syndrome (OR = 1.30, 95% CI = 1.12-1.52). CONCLUSIONS In the elderly population, different psychosocial risk factors are associated with a higher prevalence of the metabolic syndrome. Whether reduction or better management of psychosocial risk factors can improve the metabolic profile remains to be demonstrated.