Radiation-induced capsule tissue reactions around textured breast implants in a rat model
Radiation-induced capsule tissue reactions around textured breast implants in a rat model
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DOI：
10.1016/j.breast.2005.08.037
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发表时间：
2006-06-01
期刊：
影响因子：
3.9
通讯作者：
Pfleiderer, B.
中科院分区：
文献类型：
--
作者：
Eltze, E.;Schaefer, U.;Pfleiderer, B.
植入12个月后，在大鼠放射模型中评估各种填充乳房植入体周围的囊纤维化和其他并发症。皮下埋植1个月后，每组各半进行高压照射。在辐射动物中发生囊纤维化的比率更高。40%的辐射组动物和24%的非辐射组动物在植入部位发生恶性肿瘤，辐射组的有丝分裂率更高（Mann-Whitney，P = 0.008）。植入物的存在是大鼠肿瘤发展的辅助因素（卡方检验，6.927; P = 0.008），也是放射治疗的辅助因素，因为对照组动物均未发生肿瘤。应用于人类，包膜挛缩（纤维化）是放射治疗的常见并发症，而放射诱导肉瘤的发展是术后放射治疗后的罕见并发症。还需要进一步的长期随访人体研究。(c)2005爱思唯尔有限公司保留所有权利。
Capsule fibrosis and other complications around various filled breast implants were evaluated in a rat radiation model after 12 months of implantation.Model implants, one per rat, were implanted subcutaneously. One month after subcutaneous implantation, high voltage radiation followed one half each group. A higher rate of capsule fibrosis occurred in radiated animals. Malignant tumors at the implantation site developed in 40% of radiated and 24% of non-radiated animals, with a much higher rate of mitosis in the radiated group (Mann-Whitney, P = 0.008). The presence of an implant is a cofactor for tumor development in rats (chi(2)-test, 6.927; P = 0.008) as well as radiation, since none of the control animals developed tumors.Applied to humans, capsule contracture (fibrosis) is a common complication of radiation, while development of radiation-induced sarcoma is a rare complication after postoperative radiotherapy by all account. Still further long-term follow-up human studies are necessary. (c) 2005 Elsevier Ltd. All rights reserved.