The movements of fibrocytes
The movements of fibrocytes
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DOI：
10.1016/0014-4827(61)90340-8
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发表时间：
1961-01-01
期刊：
影响因子：
--
通讯作者：
AMBROSE, E. J.
中科院分区：
文献类型：
--
作者：
AMBROSE, E. J.
已有证据表明，当纤维细胞在固体底物上运动时，其主要运动机制是由于底物附近区域细胞膜的波动。细胞膜的褶皱在细胞的前缘最为明显，并向细胞核的后方移动。这种机制的证据部分来自干涉显微镜的测量结果，部分来自表面接触显微镜获得的证据，这种显微镜可以直接检查细胞膜和底物之间的接触。这表明膜的波动可能是由位于细胞质内并平行于细胞表面的收缩原纤维产生的。这些收缩在很大程度上是随机发生的，除非原纤维被张力或细胞质流动定向，从而导致细胞运动方向的极化。摘要作者：作者
Evidence has been obtained which suggests that the main locomotory mechanism in fibrocytes, when moving on a solid substrate, is due to undulations of the cell membrane in the region adjacent to the substrate. The ruffles of the membrane are most pronounced on the leading edge of the cell and travel backwards towards the nucleus. The evidence for this mechanism rests partly on measurements with the interference microscope and partly on evidence obtained with a surface contact microscope which enables the contacts between the cell membrane and the substrate to be examined directly. It is suggested that the undulations of the membrane could be produced by contractile fibrils lying just within the cytoplasm and parallel to the cell surface. These contractions occur largely at random unless the fibrils become orientated by tension or by cytoplasmic flow, so leading to polarization of the direction of movement of the cell. || ABSTRACT AUTHORS: Author